| Gene Symbol |
ADCYAP1R1
|
| Entrez Gene |
117
|
| Alt Symbol |
PAC1, PAC1R, PACAPR, PACAPRI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
|
| Other Description |
PACAP receptor 1|PACAP type I receptor|PACAP-R1|pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop|pituitary adenylate cyclase-activating polypeptide type I receptor
|
| Swissprots |
A8K1Y1 Q17S10 B7ZLA7 P41586 B8ZZK3
|
| Accessions |
AAA19323 BAC05923 EAL24444 EAW93978 P41586 AI815550 AK096545 AK124304 AK226138 AK290046 BAF82735 AY366498 AAQ72806 AY462278 AAR26314 AY462279 AAR26315 AY495951 AAR87870 AY495952 AAR87871 BC117116 AAI17117 BC136267 AAI36268 BC143679 AAI43680 BX538156 CA432770 DA809763 XM_005249618 XP_005249675 XM_006715645 XP_006715708 XM_011515117 XP_011513419 XM_011515118 XP_011513420 XM_011515119 XP_011513421 XM_011515120 XP_011513422 NM_001118 NP_001109 NM_001199635 NP_001186564 NM_001199636 NP_001186565 NM_001199637 NP_001186566
|
| Function |
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.
|
| Top Pathways |
Circadian entrainment, cAMP signaling pathway, Neuroactive ligand-receptor interaction
|