| Gene Symbol |
esc
|
| Entrez Gene |
34595
|
| Alt Symbol |
CG14941, Dmel\CG14941, ESC, Esc, L41867, dESC, sc
|
| Species |
Drosophila
|
| Gene Type |
protein-coding
|
| Description |
extra sexcombs
|
| Other Description |
CG14941-PA|esc-PA|extra Sex combs|extra sex comb
|
| Swissprots |
Q24338
|
| Accessions |
2120251A AAA86427 AAF53124 Q24338 AY069796 AAL39941 NM_058083 NP_477431
|
| Function |
Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required. {ECO:0000269|PubMed:7556071}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12533794, ECO:0000269|PubMed:7556071}.
|
| Tissue Specificity |
Widely expressed.
|