| Gene Symbol | esc |
|---|---|
| Entrez Gene | 34595 |
| Alt Symbol | CG14941, Dmel\CG14941, ESC, Esc, L41867, dESC, sc |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | extra sexcombs |
| Other Description | CG14941-PA|esc-PA|extra Sex combs|extra sex comb |
| Swissprots | Q24338 |
| Accessions | 2120251A AAA86427 AAF53124 Q24338 AY069796 AAL39941 NM_058083 NP_477431 |
| Function | Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required. {ECO:0000269|PubMed:7556071}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:12533794, ECO:0000269|PubMed:7556071}. |
| Tissue Specificity | Widely expressed. |