| Gene Symbol |
TTC28
|
| Entrez Gene |
23331
|
| Alt Symbol |
TPRBK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tetratricopeptide repeat domain 28
|
| Other Description |
TPR repeat protein 28|TPR repeat-containing big gene cloned at Keio|TPR-containing big gene cloned at Keio|tetratricopeptide repeat protein 28
|
| Swissprots |
Q5W189 O95929 Q9UGG5 K7ZRV2 Q9UG31 Q9Y3S5 Q9UPV8 Q9NTE4 Q96AY4 O95928
|
| Accessions |
CAB62963 CAB62964 CCQ43126 Q96AY4 AB028966 BAA82995 AB665284 BAM66822 AK055553 AK092338 AL080174 CAB45760 AL137328 CAB70697 BC016465 AAH16465 XM_005261405 XP_005261462 XM_006724171 XP_006724234 XM_011530018 XP_011528320 XM_011530019 XP_011528321 XM_011530020 XP_011528322 XM_011530021 XP_011528323 XM_011530022 XP_011528324 NM_015281 NM_001145418 NP_001138890
|
| Function |
During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Midbody {ECO:0000250}. Note=At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas. {ECO:0000269|PubMed:23036704}.
|