| Gene Symbol | CTDNEP1 |
|---|---|
| Entrez Gene | 23399 |
| Alt Symbol | DULLARD, HSA011916, NET56 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CTD nuclear envelope phosphatase 1 |
| Other Description | C-terminal domain nuclear envelope phosphatase 1|dullard homolog|serine/threonine-protein phosphatase dullard |
| Swissprots | D3DTN7 O95476 Q96GQ9 |
| Accessions | EAW90233 EAW90235 EAW90236 EAW90237 EAW90239 O95476 AJ011916 CAA09865 AY364239 AAQ76798 BC009295 AAH09295 DQ893130 ABM84056 DQ896409 ABM87408 NM_001143775 NP_001137247 NM_015343 NP_056158 |
| Function | Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling. {ECO:0000269|PubMed:17420445, ECO:0000269|PubMed:22134922}. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. |
| Tissue Specificity | Muscle specific with lower expression in other metabolic tissues. {ECO:0000269|PubMed:22134922}. |