| Gene Symbol |
CACNA1G
|
| Entrez Gene |
8913
|
| Alt Symbol |
Ca(V)T.1, Cav3.1, NBR13
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium channel, voltage-dependent, T type, alpha 1G subunit
|
| Other Description |
cav3.1c|voltage-dependent T-type calcium channel alpha 1G subunit|voltage-dependent T-type calcium channel subunit alpha-1G|voltage-dependent calcium channel alpha 1G subunit|voltage-gated calcium channel subunit alpha Cav3.1
|
| Swissprots |
Q9Y5T3 Q19R04 Q19QZ6 Q9UHP0 Q9NYU5 Q19QZ7 D6RA64 Q9UHN9 Q19R00 Q19QZ4 Q19R05 Q19QZ9 Q19QZ2 Q2TAC4 Q19R12 Q19QZ3 Q9NYU6 Q9NYU8 Q19R01 Q9UNG7 Q19R17 Q19R03 Q19R16 Q19QZ8 Q19R02 O43497 Q19QZ1 Q19R11 Q9NYV0 Q19R18 Q9NYV1 Q19R10 O43498 E7EPR0 Q9NYU7 O94770 Q19R06 Q19QY8 Q19R07 Q9ULU6 Q19R08 Q19R15 Q19QZ5 Q9NYU9 Q9NYU4 Q19R09 Q19R13 Q19QZ0 Q9Y5T2 Q19QY9
|
| Accessions |
CAR95114 CAR95115 CAR95116 CAR95117 CAR95118 CAR95119 CAR95120 CAR95121 CAR95122 CAR95123 CAR95124 CAR95125 CAR95126 CAR95127 CAR95128 EAW94596 EAW94597 EAW94598 EAW94599 EAW94600 EAW94601 O43497 AB012043 BAA36409 AB032949 BAA86437 AF029228 AAD12731 AF029229 AAD12732 AF124351 AAD34352 AF126965 AAD29400 AF126966 AAD29401 AF134985 AAF19346 AF134986 AAF19347 AF190860 AAF35287 AF227744 AAF37689 AF227745 AAF37690 AF227746 AAF37691 AF227747 AAF37692 AF227748 AAF37693 AF227749 AAF37694 AF227750 AAF37695 AF227751 AAF37696 AK296513 BAG59145 BC110995 AAI10996 DQ494449 ABF69900 DQ494450 ABF69901 DQ494451 ABF69902 DQ494452 ABF69903 DQ494453 ABF69904 DQ494454 ABF69905 DQ494455 ABF69906 DQ494456 ABF69907 DQ494457 ABF69908 DQ494458 ABF69909 DQ494459 ABF69910 DQ494460 ABF69911 DQ494461 ABF69912 DQ494462 ABF69913 DQ494463 ABF69914 DQ494464 ABF69915 DQ494465 ABF69916 DQ494466 ABF69917 DQ494467 ABF69918 DQ494468 ABF69919 DQ494469 ABF69920 DQ494470 ABF69921 DQ494471 ABF69922 DQ494472 ABF69923 DQ494473 ABF69924 DQ494474 ABF69925 DQ494475 ABF69926 DQ494476 ABF69927 DQ494477 ABF69928 DQ494478 ABF69929 DQ494479 ABF69930 KJ534993 AHW56633 KJ535064 AHW56703 R43876 XM_006722160 XP_006722223 XM_006722161 XP_006722224 XM_011525440 XP_011523742 NM_001256324 NP_001243253 NM_001256325 NP_001243254 NM_001256326 NP_001243255 NM_001256327 NP_001243256 NM_001256328 NP_001243257 NM_001256329 NP_001243258 NM_001256330 NP_001243259 NM_001256331 NP_001243260 NM_001256332 NP_001243261 NM_001256333 NP_001243262 NM_001256334 NP_001243263 NM_001256359 NP_001243288 NM_001256360 NP_001243289 NM_001256361 NP_001243290 NM_018896 NP_061496 NM_198376 NP_938190 NM_198377 NP_938191 NM_198378 NP_938192 NM_198379 NP_938193 NM_198380 NP_938194 NM_198382 NP_938196 NM_198383 NP_938197 NM_198384 NP_938198 NM_198385 NP_938199 NM_198386 NP_938200 NM_198387 NP_938201 NM_198388 NP_938202 NM_198396 NP_938406 NR_046054 NR_046055 NR_046056 NR_046057 NR_046058 NM_198397
|
| Function |
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression.
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| Top Pathways |
Type II diabetes mellitus, MAPK signaling pathway, Calcium signaling pathway, Circadian entrainment
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