| Gene Symbol |
TRIOBP
|
| Entrez Gene |
11078
|
| Alt Symbol |
DFNB28, HRIHFB2122, TAP68, TARA, dJ37E16.4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TRIO and F-actin binding protein
|
| Other Description |
TRIO and F-actin-binding protein|protein Tara|tara-like protein|trio-associated repeat on actin
|
| Swissprots |
Q96DW1 Q2PZW8 F2Z2W0 Q9Y3L4 F8W6V6 Q9BY98 Q9BTL7 B1AHD4 Q9BT77 Q5R3M6 Q9H2D6 B1AHD7 Q2Q400 O94797 Q2Q3Z9
|
| Accessions |
EAW60181 EAW60182 EAW60183 EAW60184 EAW60185 EAW60186 Q9H2D6 AB015343 BAA34800 AF281030 AAG44841 AK096634 AL713698 CAD28497 AM392748 CAL37626 AM392798 CAL37676 AW444985 BC003618 AAH03618 BC004303 AAH04303 BC013278 AAH13278 BC022200 BM682463 BQ880866 BU621193 BU675400 BX342673 DA790674 DQ228003 ABB59559 DQ228004 ABB59560 DQ228005 ABB59561 NM_001039141 NP_001034230 NM_007032 NP_008963 NM_138632 NP_619538
|
| Function |
May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. {ECO:0000269|PubMed:18194665}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:9853615}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9853615}. Note=Localized to F-actin in a periodic pattern.
|
| Tissue Specificity |
Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues. {ECO:0000269|PubMed:16385458}.
|