| Gene Symbol | CDC15 |
|---|---|
| Entrez Gene | 851274 |
| Alt Symbol | LYT1 |
| Species | Yeast |
| Gene Type | protein-coding |
| Description | serine/threonine protein kinase CDC15 |
| Other Description | - |
| Swissprots | P27636 D6VPM6 |
| Accessions | DAA06996 P27636 NM_001178218 NP_009411 |
| Function | Protein kinase of the mitotic exit network (MEN) essential for late nuclear division in the mitotic cycle. Promotes mitotic exit by phosphorylating DBF2 and directly switching on DBF2 kinase activity. Involved in the localization of DBF2 and DBF20 to the neck which is necessary to undergo cytokinesis. Plays a role in segregation of chromosomes during recovery from spindle checkpoint activation. Required for spindle pole localization of CDK1 and inactivation of CDC2 kinase activity at the end of mitosis. Required for spindle disassembly after meiosis II and plays a role in spore morphogenesis. {ECO:0000269|PubMed:10413604, ECO:0000269|PubMed:10744974, ECO:0000269|PubMed:11267871, ECO:0000269|PubMed:11290702, ECO:0000269|PubMed:11378390, ECO:0000269|PubMed:11404483, ECO:0000269|PubMed:11598184, ECO:0000269|PubMed:12832486, ECO:0000269|PubMed:12937277, ECO:0000269|PubMed:17660551, ECO:0000269|PubMed:20046099, ECO:0000269|PubMed:20123997, ECO:0000269|PubMed:20442249, ECO:0000269|PubMed:205 |
| Subcellular Location | Cytoplasm, cytoskeleton, spindle pole. Bud neck. Note=Localizes to the spindle pole bodies at late anaphase and translocates to the cytoplasm upon DNA replication stress. Localization to SPBs depends on CDC5 and TEM1 and is inhibited by BUB2. Accumulates at the daughter SPB after anaphase onset when the daughter SPB begins to penetrate the bud neck. Not found in the mother SPD during early anaphase. As anaphase proceeds, continues to accumulate on the daughter SPB and also localizes to the mother SPB. At the end of telophase, a portion of CDC15 localizes at the mother-bud neck. |
| Top Pathways | Cell cycle - yeast, Meiosis - yeast |
Cdc15 (yC-13) - sc-27897 from Santa Cruz Biotechnology
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Cdc15 (yN-14) - sc-27895 from Santa Cruz Biotechnology
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