CDC15

Gene Symbol CDC15
Entrez Gene 851274
Alt Symbol LYT1
Species Yeast
Gene Type protein-coding
Description serine/threonine protein kinase CDC15
Other Description -
Swissprots P27636 D6VPM6
Accessions DAA06996 P27636 NM_001178218 NP_009411
Function Protein kinase of the mitotic exit network (MEN) essential for late nuclear division in the mitotic cycle. Promotes mitotic exit by phosphorylating DBF2 and directly switching on DBF2 kinase activity. Involved in the localization of DBF2 and DBF20 to the neck which is necessary to undergo cytokinesis. Plays a role in segregation of chromosomes during recovery from spindle checkpoint activation. Required for spindle pole localization of CDK1 and inactivation of CDC2 kinase activity at the end of mitosis. Required for spindle disassembly after meiosis II and plays a role in spore morphogenesis. {ECO:0000269|PubMed:10413604, ECO:0000269|PubMed:10744974, ECO:0000269|PubMed:11267871, ECO:0000269|PubMed:11290702, ECO:0000269|PubMed:11378390, ECO:0000269|PubMed:11404483, ECO:0000269|PubMed:11598184, ECO:0000269|PubMed:12832486, ECO:0000269|PubMed:12937277, ECO:0000269|PubMed:17660551, ECO:0000269|PubMed:20046099, ECO:0000269|PubMed:20123997, ECO:0000269|PubMed:20442249, ECO:0000269|PubMed:205
Subcellular Location Cytoplasm, cytoskeleton, spindle pole. Bud neck. Note=Localizes to the spindle pole bodies at late anaphase and translocates to the cytoplasm upon DNA replication stress. Localization to SPBs depends on CDC5 and TEM1 and is inhibited by BUB2. Accumulates at the daughter SPB after anaphase onset when the daughter SPB begins to penetrate the bud neck. Not found in the mother SPD during early anaphase. As anaphase proceeds, continues to accumulate on the daughter SPB and also localizes to the mother SPB. At the end of telophase, a portion of CDC15 localizes at the mother-bud neck.
Top Pathways Cell cycle - yeast, Meiosis - yeast