| Gene Symbol | AK9 |
|---|---|
| Entrez Gene | 221264 |
| Alt Symbol | AK 9, AKD1, AKD2, C6orf199, C6orf224, dJ70A9.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | adenylate kinase 9 |
| Other Description | adenylate kinase domain containing 1|adenylate kinase domain containing 2 |
| Swissprots | Q5I0W8 B2RDJ0 Q8N7C6 A6NL75 Q5TCS8 Q3MIS4 Q6ZNF1 Q96NF4 Q6ZVR7 B6ZDM7 Q8WW00 |
| Accessions | EAW48333 EAW48334 EAW48335 EAW48336 Q5TCS8 AK055538 BAB70945 AK098657 BAC05368 AK124171 AK131244 BAD18424 AK315561 BAG37937 AL832162 BC022031 AAH22031 BC087860 AAH87860 BC101714 AAI01715 BC111948 AAI11949 BC143533 AAI43534 BC146443 AAI46444 BC153055 AAI53056 DA106296 DW009925 EU831612 ACE87212 EU831699 ACE86533 XM_006715376 XP_006715439 XM_011535550 XP_011533852 XM_011535551 XP_011533853 XM_011535552 XP_011533854 XM_011535553 XP_011533855 XM_011535554 XP_011533856 XM_011535555 XP_011533857 XM_011535556 XP_011533858 XM_011535557 XP_011533859 XM_011535558 XP_011533860 XM_011535559 XP_011533861 XR_942337 XR_942338 NM_001145128 NP_001138600 NM_145025 NP_659462 NM_001001706 NM_173559 |
| Function | Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP. {ECO:0000269|PubMed:23416111}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:23416111}. Nucleus {ECO:0000269|PubMed:23416111}. |
| Top Pathways | Purine metabolism, Pyrimidine metabolism |
AKD1 CRISPR/Cas9 KO Plasmid (h) - sc-415123 from Santa Cruz Biotechnology
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AKD1 HDR Plasmid (h) - sc-415123-HDR from Santa Cruz Biotechnology
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AKD1 Double Nickase Plasmid (h) - sc-415123-NIC from Santa Cruz Biotechnology
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AKD1 Double Nickase Plasmid (h2) - sc-415123-NIC-2 from Santa Cruz Biotechnology
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AKD1 CRISPR Activation Plasmid (h) - sc-415123-ACT from Santa Cruz Biotechnology
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AKD1 CRISPR Activation Plasmid (h2) - sc-415123-ACT-2 from Santa Cruz Biotechnology
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AKD1 Lentiviral Activation Particles (h) - sc-415123-LAC from Santa Cruz Biotechnology
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AKD1 Lentiviral Activation Particles (h2) - sc-415123-LAC-2 from Santa Cruz Biotechnology
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AKD1 siRNA (h) - sc-95233 from Santa Cruz Biotechnology
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AKD1 shRNA Plasmid (h) - sc-95233-SH from Santa Cruz Biotechnology
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AKD1 shRNA (h) Lentiviral Particles - sc-95233-V from Santa Cruz Biotechnology
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AKD1 RNAi - H00221264-R02 from Novus Biologicals
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MISSION® esiRNA - EHU003031 from Sigma-Aldrich
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MISSION® siRNA - SIHK0216 from Sigma-Aldrich
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MISSION® siRNA - SIHK0218 from Sigma-Aldrich
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MISSION® siRNA - SIHK0217 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3017 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3017 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08822 from Sigma-Aldrich
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AK9 siRNA (Human) - CRJ6500 from Cohesion Biosciences
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AK9 - MBS8237243 from MyBioSource
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shRNA set against Human AKD1 (NM_001145128.2) - SHH234358 from Creative biogene
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shRNA set against Human C6orf199(NM_145025.4) - SHG127351 from Creative biogene
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Human AK9 siRNA - orb277001 from Biorbyt
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AK9 shRNA Plasmid (Human) - CHJ6500 from Cohesion Biosciences
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