Gene Symbol | CSGALNACT1 |
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Entrez Gene | 55790 |
Alt Symbol | CSGalNAcT-1, ChGn, beta4GalNAcT |
Species | Human |
Gene Type | protein-coding |
Description | chondroitin sulfate N-acetylgalactosaminyltransferase 1 |
Other Description | beta4GalNAcT-1|chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1|chondroitin beta1,4 N-acetylgalactosaminyltransferase |
Swissprots | Q8IUF9 B2RBE4 Q9NUM9 Q8TDX6 Q9NSQ7 Q6P9G6 |
Accessions | EAW63770 EAW63771 EAW63772 Q8TDX6 AB071403 BAB85992 AB081516 BAC16217 AK002124 AK002126 BAA92093 AK023822 AK055154 BAG51476 AK314625 BAG37191 AL157483 CAB75673 AY358441 AAQ88806 BC060772 AAH60772 BQ016671 BX104931 BX649103 CR998055 DA244956 DA404904 DA981630 XM_006716358 XP_006716421 XM_006716359 XP_006716422 XM_006716360 XP_006716423 XM_006716361 XP_006716424 XM_006716362 XP_006716425 XM_006716363 XP_006716426 XM_006716364 XP_006716427 XM_011544577 XP_011542879 XM_011544578 XP_011542880 XM_011544579 XP_011542881 XM_011544580 XP_011542882 XM_011544581 XP_011542883 XM_011544582 XP_011542884 XM_011544583 XP_011542885 XM_011544584 XP_011542886 XM_011544585 XP_011542887 XR_949441 NM_001130518 NP_001123990 NM_018371 NP_060841 NR_024040 |
Function | Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage. {ECO:0000269|PubMed:11788602, ECO:0000269|PubMed:12163485, ECO:0000269|PubMed:12446672, ECO:0000269|PubMed:17145758}. |
Subcellular Location | Golgi apparatus, Golgi stack membrane {ECO:0000305|PubMed:11788602}; Single-pass type II membrane protein {ECO:0000305|PubMed:11788602}. |
Tissue Specificity | Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined. {ECO:0000269|PubMed:11788602, ECO:0000269|PubMed:12163485, ECO:0000269|PubMed:12446672}. |
Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
β-1,4-GalNAc-T (Q-20) - sc-87539 from Santa Cruz Biotechnology
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Anti-CSGALNACT1 antibody - ab111304 from Abcam
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Anti-CSGALNACT1 antibody - ab83071 from Abcam
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Anti-CSGALNACT1 antibody - ab104305 from Abcam
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Anti-CSGALNACT1 antibody - ab67128 from Abcam
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Anti-CSGALNACT1 Antibody (aa200-230, APC) - LS-C234300 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody (aa200-230, AP) - LS-C234299 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody (aa200-230, Biotin) - LS-C234302 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody (aa201-250) - LS-C119850 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody (aa200-230, FITC) - LS-C234303 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody (aa200-230, PE) - LS-C234304 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody (aa200-230, Azide-free, HRP) - LS-C249768 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody - LS-C306937 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody (aa130-179) - LS-C81056 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody - LS-C310007 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody - LS-C310011 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody (C-Terminus) - LS-C81057 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody (aa200-230) - LS-C320629 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody (N-Terminus) - LS-C345781 from LifeSpan Bioscience
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Anti-CSGALNACT1 Antibody (aa200-230) - LS-C167083 from LifeSpan Bioscience
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ChGn Antibody - NBP1-59218 from Novus Biologicals
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ChGn Antibody - NBP1-59219 from Novus Biologicals
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ChGn Antibody - H00055790-B02P from Novus Biologicals
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ChGn Antibody - H00055790-B02 from Novus Biologicals
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ChGn Antibody - NBP1-55987 from Novus Biologicals
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