ANO1
| Gene Symbol | ANO1 |
|---|---|
| Entrez Gene | 55107 |
| Alt Symbol | DOG1, ORAOV2, TAOS2, TMEM16A |
| Species | Human |
| Gene Type | protein-coding |
| Description | anoctamin 1, calcium activated chloride channel |
| Other Description | Ca2+-activated Cl- channel|anoctamin-1|discovered on gastrointestinal stromal tumors protein 1|oral cancer overexpressed 2|transmembrane protein 16A (eight membrane-spanning domains)|tumor-amplified and overexpressed sequence 2 |
| Swissprots | Q5XXA6 Q8IYY8 A8KAM3 Q8N7V3 |
| Accessions | EAW74757 EAW74758 EAW74759 Q5XXA6 AB845669 BAO49755 AI694083 AK001123 BAA91513 AK097619 BAC05123 AK293088 BAF85777 AK303971 BAH14087 AL833582 AY728143 AAU82085 BC027590 AAH27590 BC033036 AAH33036 CF593428 DB445158 DB450993 HQ418153 ADP09411 XM_006718602 XP_006718665 XM_006718604 XP_006718667 XM_006718605 XP_006718668 XM_011545121 XP_011543423 XM_011545122 XP_011543424 XM_011545123 XP_011543425 XM_011545124 XP_011543426 XM_011545125 XP_011543427 XM_011545126 XP_011543428 XM_011545127 XP_011543429 XM_011545128 XP_011543430 XM_011545129 XP_011543431 XM_011545130 XP_011543432 XM_011545131 XP_011543433 NM_018043 NP_060513 NR_030691 |
| Function | Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21984732, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors. |
| Tissue Specificity | Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles. {ECO:0000269|PubMed:15215166, ECO:0000269|PubMed:16906560}. |
Human TMEM16A peptide - ab97423 from Abcam
|
||||||||||
ANO1 / DOG1 / TMEM16A Antibody Blocking Peptide - LS-E5800 from LifeSpan Bioscience
|
||||||||||
ANO1 / DOG1 / TMEM16A Antibody Blocking Peptide - LS-E30787 from LifeSpan Bioscience
|
||||||||||
ANO1 / DOG1 / TMEM16A Antibody Blocking Peptide - LS-E15649 from LifeSpan Bioscience
|
||||||||||
DOG1/TMEM16A Blocking Peptide - NBP2-29662PEP from Novus Biologicals
|
||||||||||
DOG1/TMEM16A Blocking Peptide - NBP1-76259PEP from Novus Biologicals
|
||||||||||
ANO1-Antibody-Center-Blocking-Peptide - BP18347c from Abgent, a WuXi AppTec company
|
||||||||||
TMEM16A Peptide - GTX85012-PEP from GeneTex
|
||||||||||
TMEM16A Blocking Peptide - 33R-3735 from Fitzgerald
|
||||||||||
ANO1 Blocking Peptide - abx161269 from Abbexa
|
||||||||||
ANO1 / DOG1 control peptide - AP10351CP-N from Acris Antibodies
|
||||||||||
ANO1 / DOG1 Control Peptide - AP30909CP-N from Acris Antibodies
|
||||||||||
TMEM16A Peptide - 5419P from ProSci
|
||||||||||
ANO1,DOG1 fusion protein - ag3320 from Proteintech Group
|
||||||||||
hTMEM16A-HEK293 Recombinant Cell line - GWB-PSE2BB from Genway Biotech
|
||||||||||
Recombinant Anoctamin 1 (ANO1) - RPB384Mu01 from Uscn Life Science Inc.
|
||||||||||
ANO1 Blocking Peptide - CBP3768 from Cohesion Biosciences
|
||||||||||
Anoctamin-1 peptide - pep0401 from Covalab
|
||||||||||
Anoctamin 1, Recombinant Protein - MBS2029536 from MyBioSource
|
||||||||||
DOG1/TMEM16A Recombinant Protein Antigen - NBP2-14296PEP from Novus Biologicals
|
||||||||||
ANO1 Peptide, Human - M34GP00675H from Creative Peptides
|