DMTN

Gene Symbol	DMTN
Entrez Gene	2039
Alt Symbol	DMT, EPB49
Species	Human
Gene Type	protein-coding
Description	dematin actin binding protein
Other Description	dematin|erythrocyte membrane protein band 4.9 (dematin)
Swissprots	Q08495 Q9BRE3 Q13215 B3KRH3 B3KP70 A8K0T5 B4DI75 E9PEJ0
Accessions	EAW63724 EAW63725 EAW63726 Q08495 AB209718 BAD92955 AK055842 BAG51582 AK091581 BAG52385 AK289650 BAF82339 AK295452 BAG58387 AK308807 BC006318 AAH06318 BC017445 AAH17445 BC052805 AAH52805 BF448882 BI222385 BT007396 AAP36060 DA131656 DA170493 DA261872 DA372459 DA521027 DA634148 DQ892779 ABM83705 DQ896026 ABM87025 EU832675 ACE87766 EU832755 ACE87087 L19713 AAA58438 U28389 AAC50223 XM_005273431 XP_005273488 XM_005273432 XP_005273489 XM_005273433 XP_005273490 XM_005273434 XP_005273491 XM_005273435 XP_005273492 XM_005273436 XP_005273493 XM_005273439 XP_005273496 XM_005273440 XP_005273497 XM_005273441 XP_005273498 XM_005273442 XP_005273499 XM_005273443 XP_005273500 XM_005273446 XP_005273503 XM_011544435 XP_011542737 XM_011544436 XP_011542738 XM_011544437 XP_011542739 XM_011544438 XP_011542740 XM_011544439 XP_011542741 NM_001114135 NP_001107607 NM_001114136 NP_001107608 NM_001114137 NP_001107609 NM_001114138 NP_001107610 NM_001114139 NP_001107611 NM_001302816 NP_001289745 NM_001302817 NP_001289746 NM_001978 NP_001969
Function	Membrane-cytoskeleton-associated protein with F-actin- binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motili
Subcellular Location	Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton. Cell membrane. Membrane {ECO:0000250}. Endomembrane system. Cell projection {ECO:0000250}. Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuol in malaria- infected erythrocytes at late stages of plasmodium berghei or falciparum development.
Tissue Specificity	Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney. {ECO:0000269|PubMed:23060452}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Dematin (G-14) - sc-26059 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Dematin (18) - sc-135881 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Anti-Dematin (phospho S403) antibody - ab61044 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Dematin antibody - ab89161 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-Dematin antibody - ab61155 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Dematin antibody - ab129699 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DMTN / Dematin Antibody (aa248-277, APC) - LS-C256739 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DMTN / Dematin Antibody (aa248-277, AP) - LS-C256738 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DMTN / Dematin Antibody (aa248-277, Biotin) - LS-C256740 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DMTN / Dematin Antibody (aa248-277, FITC) - LS-C256741 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DMTN / Dematin Antibody (aa248-277, Azide-free, HRP) - LS-C256742 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DMTN / Dematin Antibody (aa142-191) - LS-C145567 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DMTN / Dematin Antibody (aa248-277, PE) - LS-C256743 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DMTN / Dematin Antibody (C-Terminus) - LS-C201722 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DMTN / Dematin Antibody - LS-C307935 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-DMTN / Dematin Antibody (phospho-Ser403) - LS-C198878 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DMTN / Dematin Antibody (aa249-277) - LS-C167783 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DMTN / Dematin Antibody (Glu397) - LS-C176504 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DMTN / Dematin Antibody (aa248-277) - LS-C329505 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DMTN / Dematin Antibody (aa356-405) - LS-C117881 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Dematin Antibody - NBP1-19383 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Dematin Antibody - NBP1-85007 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Dematin Antibody - H00002039-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Dematin Antibody - H00002039-B01 from Novus Biologicals Host Mouse Clonality Polyclonal

Anti-Dematin, C-Terminal antibody produced in rabbit - SAB4500773 from Sigma-Aldrich Prices $335.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

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