| Gene Symbol | Myog |
|---|---|
| Entrez Gene | 17928 |
| Alt Symbol | MYF4, bHLHc3, myo |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | myogenin |
| Other Description | MYOD1-related protein |
| Swissprots | P12979 |
| Accessions | AAB59676 CAA50725 EDL39619 EDL39620 P12979 AB221643 BC048683 AAH48683 BC068019 AAH68019 CJ096370 D90156 BAA14187 X15784 CAA33785 NM_031189 NP_112466 |
| Function | Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin- remodeling enzymes to alter chromatin structure at myogenic lat |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:16424906}. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos. |
| Tissue Specificity | Expressed in myoblast cells. Expressed weakly in myotubes (at protein level). Expressed strongly in denervated muscles and in satellite cells isolated from denervated muscles. Expressed weakly in innervated muscle and in satellite cells isolated from innervated muscles. {ECO:0000269|PubMed:21465538, ECO:0000269|PubMed:21798092}. |
myogenin CRISPR/Cas9 KO Plasmid (m) - sc-421806 from Santa Cruz Biotechnology
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myogenin HDR Plasmid (m) - sc-421806-HDR from Santa Cruz Biotechnology
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myogenin Double Nickase Plasmid (m) - sc-421806-NIC from Santa Cruz Biotechnology
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myogenin Double Nickase Plasmid (m2) - sc-421806-NIC-2 from Santa Cruz Biotechnology
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myogenin CRISPR Activation Plasmid (m) - sc-421806-ACT from Santa Cruz Biotechnology
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myogenin CRISPR Activation Plasmid (m2) - sc-421806-ACT-2 from Santa Cruz Biotechnology
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myogenin Lentiviral Activation Particles (m) - sc-421806-LAC from Santa Cruz Biotechnology
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myogenin Lentiviral Activation Particles (m2) - sc-421806-LAC-2 from Santa Cruz Biotechnology
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myogenin siRNA (m) - sc-35992 from Santa Cruz Biotechnology
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myogenin shRNA Plasmid (m) - sc-35992-SH from Santa Cruz Biotechnology
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myogenin shRNA (m) Lentiviral Particles - sc-35992-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN36119 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36119 from Sigma-Aldrich
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MYOG siRNA (Mouse) - CRM2692 from Cohesion Biosciences
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shRNA set against Mouse MYOG (NM_031189.2) - SHH348408 from Creative biogene
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myogenin CRISPR/Cas9 KO Plasmid (m2) - sc-421806-KO-2 from Santa Cruz Biotechnology
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myogenin HDR Plasmid (m2) - sc-421806-HDR-2 from Santa Cruz Biotechnology
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MYOG shRNA Plasmid (Mouse) - CHM2692 from Cohesion Biosciences
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MYOG miRNA 3'UTR clone - MiUTR1M-07470 from Creative biogene
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