| Gene Symbol | Pold1 |
|---|---|
| Entrez Gene | 18971 |
| Alt Symbol | 125kDa |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | polymerase (DNA directed), delta 1, catalytic subunit |
| Other Description | DNA polymerase delta 1, catalytic domain|DNA polymerase delta catalytic subunit |
| Swissprots | O54883 Q3TFX6 P52431 |
| Accessions | AAB99910 CAH68810 EDL22729 EDL22730 EDL22731 EDL22732 EDL22733 EDL22734 P52431 AK088310 BAC40275 AK146837 AK166592 AK167569 BAE39632 AK168967 BAE40772 AK169040 BAE40829 AK186033 AK190332 AK196295 BC009128 AAH09128 BC052670 AAH52670 BX634546 CJ173955 Z21848 CAA79895 NM_011131 NP_035261 |
| Function | Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex. |
| Subcellular Location | Nucleus. |
| Top Pathways | HTLV-I infection, Nucleotide excision repair, Base excision repair, Homologous recombination, Mismatch repair |
DNA pol δ cat siRNA (m) - sc-37778 from Santa Cruz Biotechnology
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DNA pol δ cat shRNA Plasmid (m) - sc-37778-SH from Santa Cruz Biotechnology
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DNA pol δ cat shRNA (m) Lentiviral Particles - sc-37778-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU016741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN39010 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39010 from Sigma-Aldrich
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POLD1 siRNA (Mouse) - CRM3156 from Cohesion Biosciences
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shRNA set against Mouse POLD1 (NM_011131.3) - SHH379096 from Creative biogene
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POLD1 shRNA Plasmid (Mouse) - CHM3156 from Cohesion Biosciences
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