Gene Symbol | CENPH |
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Entrez Gene | 64946 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | centromere protein H |
Other Description | CENP-H|interphase centromere complex protein 35|kinetochore protein CENP-H |
Swissprots | A8K3Y1 Q9H3R5 |
Accessions | CAK32316 EAW51304 EAW51305 Q9H3R5 AB035124 BAB18635 AK123761 BAG53955 AK290746 BAF83435 BC012024 AAH12024 BC015355 AAH15355 DQ894658 ABM85584 NM_022909 NP_075060 |
Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:14536089, ECO:0000269|PubMed:16875666, ECO:0000269|PubMed:18007590}. |
Subcellular Location | Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase. |
CENP-H CRISPR/Cas9 KO Plasmid (h) - sc-404498 from Santa Cruz Biotechnology
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CENP-H HDR Plasmid (h) - sc-404498-HDR from Santa Cruz Biotechnology
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CENP-H Double Nickase Plasmid (h) - sc-404498-NIC from Santa Cruz Biotechnology
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CENP-H Double Nickase Plasmid (h2) - sc-404498-NIC-2 from Santa Cruz Biotechnology
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CENP-H CRISPR Activation Plasmid (h) - sc-404498-ACT from Santa Cruz Biotechnology
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CENP-H CRISPR Activation Plasmid (h2) - sc-404498-ACT-2 from Santa Cruz Biotechnology
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CENP-H Lentiviral Activation Particles (h) - sc-404498-LAC from Santa Cruz Biotechnology
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CENP-H Lentiviral Activation Particles (h2) - sc-404498-LAC-2 from Santa Cruz Biotechnology
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CENP-H siRNA (h) - sc-37565 from Santa Cruz Biotechnology
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CENP-H shRNA Plasmid (h) - sc-37565-SH from Santa Cruz Biotechnology
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CENP-H shRNA (h) Lentiviral Particles - sc-37565-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU040731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5943 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5943 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05142 from Sigma-Aldrich
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CENPH siRNA (Human) - CRJ2146 from Cohesion Biosciences
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CENPH - MBS8232606 from MyBioSource
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shRNA set against Human CENPH(NM_022909.3) - SHG168009 from Creative biogene
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Human CENPH siRNA - orb272647 from Biorbyt
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CENPH shRNA Plasmid (Human) - CHJ2146 from Cohesion Biosciences
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CENPH miRNA 3'UTR clone - MiUTR1H-02039 from Creative biogene
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