POLDIP3
| Gene Symbol | POLDIP3 |
|---|---|
| Entrez Gene | 84271 |
| Alt Symbol | PDIP46, SKAR |
| Species | Human |
| Gene Type | protein-coding |
| Description | polymerase (DNA-directed), delta interacting protein 3 |
| Other Description | 46 kDa DNA polymerase delta interaction protein|RNA-binding protein P46|S6K1 Aly/REF-like target|polymerase delta-interacting protein 3 |
| Swissprots | A8K6F8 Q9NSP5 Q9NSP6 A8K6V9 Q6PGN6 Q9BY77 Q5H972 Q7Z6Z0 Q009A7 |
| Accessions | AAQ94604 EAW73264 EAW73265 EAW73266 EAW73267 Q9BY77 AB055760 BAB33368 AK024626 AK291623 BAF84312 AK291774 BAF84463 AK297532 BAG59934 AK299751 BAG61641 AK303419 BAG64472 AL080227 AL137743 CAH56378 AL160111 CAB77058 AL160112 CAB77059 AY506562 AAR91612 BC001488 AAH01488 BC007397 BC019643 AAH19643 BC049840 AAH49840 BC056912 AAH56912 BC095411 AAH95411 BE268664 CR456456 CAG30342 CU013006 CAK54437 CU013294 CAK54736 DC368557 DQ887818 ABI74675 XM_011530457 XP_011528759 XR_937942 NM_001278657 NP_001265586 NM_032311 NP_115687 NM_178136 NP_835237 NR_103820 |
| Function | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Subcellular Location | Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. |
POLDIP3 CRISPR/Cas9 KO Plasmid (h) - sc-413603 from Santa Cruz Biotechnology
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POLDIP3 HDR Plasmid (h) - sc-413603-HDR from Santa Cruz Biotechnology
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POLDIP3 Double Nickase Plasmid (h) - sc-413603-NIC from Santa Cruz Biotechnology
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POLDIP3 Double Nickase Plasmid (h2) - sc-413603-NIC-2 from Santa Cruz Biotechnology
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POLDIP3 CRISPR Activation Plasmid (h) - sc-413603-ACT from Santa Cruz Biotechnology
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POLDIP3 CRISPR Activation Plasmid (h2) - sc-413603-ACT-2 from Santa Cruz Biotechnology
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POLDIP3 Lentiviral Activation Particles (h) - sc-413603-LAC from Santa Cruz Biotechnology
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POLDIP3 Lentiviral Activation Particles (h2) - sc-413603-LAC-2 from Santa Cruz Biotechnology
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POLDIP3 siRNA (h) - sc-76192 from Santa Cruz Biotechnology
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POLDIP3 shRNA Plasmid (h) - sc-76192-SH from Santa Cruz Biotechnology
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POLDIP3 shRNA (h) Lentiviral Particles - sc-76192-V from Santa Cruz Biotechnology
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SKAR RNAi - H00084271-R02 from Novus Biologicals
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SKAR RNAi - H00084271-R01 from Novus Biologicals
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MISSION® esiRNA - EHU123501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17093 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17093 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12831 from Sigma-Aldrich
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POLDIP3 siRNA (Human) - CRJ3397 from Cohesion Biosciences
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shRNA set against Human POLDIP3 (NM_178136.1) - SHH379152 from Creative biogene
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shRNA set against Human POLDIP3(NM_032311.3) - SHR126456 from Creative biogene
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shRNA set against Human POLDIP3(NM_178136.1) - SHR126474 from Creative biogene
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POLDIP3 shRNA Plasmid (Human) - CHJ3397 from Cohesion Biosciences
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POLDIP3 miRNA 3'UTR clone - MiUTR1H-08063 from Creative biogene
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POLDIP3 miRNA 3'UTR clone - MiUTR1H-08064 from Creative biogene
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