| Gene Symbol | COPB1 |
|---|---|
| Entrez Gene | 1315 |
| Alt Symbol | COPB |
| Species | Human |
| Gene Type | protein-coding |
| Description | coatomer protein complex, subunit beta 1 |
| Other Description | beta coat protein|beta-coat protein|beta-cop|coatomer subunit beta |
| Swissprots | Q9NTK2 P53618 Q6GTT7 Q9UNW7 D3DQX0 |
| Accessions | EAW68481 EAW68482 EAW68483 EAW68484 EAW68485 P53618 AA443270 AF084457 AAD41240 AF111807 AAL39009 AK001203 AK128844 AL136593 CAB66528 AM393381 CAL38259 BC012572 BC037280 AAH37280 DA725605 DB455108 DQ892479 ABM83405 DQ895690 ABM86616 X82103 CAA57622 NM_001144061 NP_001137533 NM_001144062 NP_001137534 NM_016451 NP_057535 |
| Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa- type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipi |
| Subcellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Endoplasmic reticulum- Golgi intermediate compartment. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Proteolytic cleavage by CAPN8 triggers translocation from Golgi to cytoplasm (By similarity). Found in perinuclear vesicular-tubular clusters (VTCs) and in the Golgi region where associated with vesicles, buds and rims of the Golgi stack (By similarity). Occasionally present at the trans-side of Golgi, but mainly present at the cis- Golgi side in transitional areas (TA), on so-called peripheral elements (PE) consisting of tubules and vesicles located between the cup-shaped transitional elements (TE) of the rough endoplasmic reticulum (RER) and the cis-most Golgi cisternae (By similarity). Present in cy |
COPB CRISPR/Cas9 KO Plasmid (h) - sc-404275 from Santa Cruz Biotechnology
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COPB HDR Plasmid (h) - sc-404275-HDR from Santa Cruz Biotechnology
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COPB Double Nickase Plasmid (h) - sc-404275-NIC from Santa Cruz Biotechnology
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COPB Double Nickase Plasmid (h2) - sc-404275-NIC-2 from Santa Cruz Biotechnology
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COPB CRISPR Activation Plasmid (h) - sc-404275-ACT from Santa Cruz Biotechnology
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COPB CRISPR Activation Plasmid (h2) - sc-404275-ACT-2 from Santa Cruz Biotechnology
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COPB Lentiviral Activation Particles (h) - sc-404275-LAC from Santa Cruz Biotechnology
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COPB Lentiviral Activation Particles (h2) - sc-404275-LAC-2 from Santa Cruz Biotechnology
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COPB siRNA (h) - sc-41196 from Santa Cruz Biotechnology
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COPB shRNA Plasmid (h) - sc-41196-SH from Santa Cruz Biotechnology
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COPB shRNA (h) Lentiviral Particles - sc-41196-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU056221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6426 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6426 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02570 from Sigma-Aldrich
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COPB1 siRNA (Human) - CRH0926 from Cohesion Biosciences
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beta COP RNAi - H00001315-R01 from Novus Biologicals
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COPB1 - MBS826913 from MyBioSource
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shRNA set against Human COPB1 (NM_016451.4) - SHH267737 from Creative biogene
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Human COPB1 siRNA - orb261428 from Biorbyt
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COPB1 shRNA Plasmid (Human) - CHH0926 from Cohesion Biosciences
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COPB1 miRNA 3'UTR clone - MiUTR3H-03772 from Creative biogene
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COPB1 miRNA 3'UTR clone - MiUTR3H-03773 from Creative biogene
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COPB1 miRNA 3'UTR clone - MiUTR3H-03774 from Creative biogene
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