CCR5

Gene Symbol CCR5
Entrez Gene 1234
Alt Symbol CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Species Human
Gene Type protein-coding
Description chemokine (C-C motif) receptor 5 (gene/pseudogene)
Other Description C-C chemokine receptor type 5|C-C motif chemokine receptor 5 A159A|HIV-1 fusion coreceptor|chemokine receptor CCR5|chemr13
Swissprots O14706 O14693 O14699 O14708 Q9UPA4 O14705 O14697 O14702 O14703 P51681 O14701 O15538 O14696 O14700 O14698 O14704 O14695 O14692 O14707
Accessions AAB09551 AAB57793 AAB94735 AAC23944 AAC51797 AAC52069 AAD18131 AAD47666 AAD47667 AAD47668 AAD47669 AAD47670 AAD47671 AAD47672 AAD47673 AAD47674 AAD47675 AAD47676 AAD47677 AAD47678 AAF65577 AAF65578 AAF65579 AAO65971 AAS19312 AAS19313 AAS19314 AAW62445 AAW82037 AAW82038 AAW82039 AAY23359 ABB01004 ABD66509 ABD66510 ABD66511 ABN10015 ABQ53533 ABQ53534 ABQ95606 ABQ95607 ABQ95608 ABU55681 ABU55682 ABU55683 ACX50405 ADC94815 AEZ06624 AEZ06625 AEZ06626 AEZ06627 AEZ06628 AEZ06629 AEZ06630 AEZ06631 AEZ06632 AEZ06633 AEZ06634 AEZ06635 AEZ06636 AEZ06637 AEZ06638 AEZ06639 AEZ06640 AEZ06641 AEZ06642 AEZ06643 AEZ06644 AEZ06645 AEZ06646 AEZ06647 AEZ06648 AEZ06649 AEZ06650 AEZ06651 AEZ06652 AEZ06653 AEZ06654 AEZ06655 AEZ06656 AEZ06657 AEZ06658 AEZ06659 AEZ06660 AEZ06661 AEZ06662 AEZ06663 AEZ06664 AEZ06665 AEZ06666 AEZ06667 AEZ06668 AEZ06669 AEZ06670 AEZ06671 AEZ06672 AEZ06673 AEZ06674 AFP99926 AFP99927 AFP99928 AFP99929 AFP99930 AFP99931 AFP99932 AFP99933 AGC13086 AGC13087 AGC13088 AGC13089 AGC13090 AGC13091 AGC13092 AGC13093 AGC13094 AGC13095 AIP93476 AIP93477 AIP93478 AIP93479 AIP93480 AIP93481 AIP93482 AIP93483 AIP93484 AIP93485 AIP93486 AIP93487 AIP93488 AIP93489 AIP93490 AIP93491 AIP93492 AIP93493 AIP93494 AIP93495 AIP93496 AIP93497 AIP93498 AIP93499 AIP93500 AIP93501 AIP93502 AIP93503 AIP93504 AIP93505 AIP93506 AIP93507 AIP93508 AIP93509 AIP93510 AIP93511 AIP93512 AIP93513 AIP93514 AIP93515 AIP93516 AIP93517 AIP93518 AIP93519 AIP93520 AIP93521 AIP93522 AIP93523 AIP93524 AIP93525 AIP93526 AIP93527 AIP93528 AIP93529 AIP93530 AIP93531 AIP93532 AIP93533 AIP93534 AIP93535 AIP93536 AIP93537 AIP93538 AIP93539 AIP93540 AIP93541 AIP93542 AIP93543 AIP93544 AIP93545 AIP93546 AIP93547 AIP93548 AIP93549 AIP93550 AIP93551 AIP93552 AIP93553 AIP93554 AIP93555 AIP93556 AIP93557 AIP93558 AIP93559 AIP93560 AIP93561 AIP93562 AIP93563 AIP93564 AIP93565 AIP93566 BAD83804 BAD83805 BAD83806 BAD83807 BAD83808 CAA62796 CAA67767 CAC94550 CAD88097 CAR96699 CBJ06541 EAW64763 EAW64764 P51681 AF011500 AAB65700 AF011501 AAB65701 AF011502 AAB65702 AF011503 AAB65703 AF011504 AAB65704 AF011505 AAB65705 AF011506 AAB65706 AF011507 AAB65707 AF011508 AAB65708 AF011509 AAB65709 AF011510 AAB65710 AF011511 AAB65711 AF011512 AAB65712 AF011513 AAB65713 AF011514 AAB65714 AF011515 AAB65715 AF011516 AAB65716 AF011517 AAB65717 AF011518 AAB65718 AF011519 AAB65719 AF011520 AAB65720 AF011521 AAB65721 AF011522 AAB65722 AF011523 AAB65723 AF011524 AAB65724 AF011525 AAB65725 AF011526 AAB65726 AF011527 AAB65727 AF011528 AAB65728 AF011529 AAB65729 AF011530 AAB65730 AF011531 AAB65731 AF011532 AAB65732 AF011533 AAB65733 AF011534 AAB65734 AF011535 AAB65735 AF011536 AAB65736 AF011537 AAB65737 AK292132 BAF84821 AK314882 BC038398 AAH38398 DA818906 U54994 AAC50598 U57840 AAB17071 NM_000579 NP_000570 NM_001100168 NP_001093638
Function Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. {ECO:0000269|PubMed:11323418, ECO:0000269|PubMed:8639485, ECO:0000269|PubMed:8649511, ECO:0000269|PubMed:8649512, ECO:0000269|PubMed:8663314, ECO:0000269|PubMed:8699119}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:11323418}; Multi-pass membrane protein {ECO:0000269|PubMed:11323418}.
Tissue Specificity Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. {ECO:0000269|PubMed:8639485, ECO:0000269|PubMed:8663314}.
Top Pathways Cytokine-cytokine receptor interaction, Endocytosis, Chemokine signaling pathway, Toxoplasmosis, Viral carcinogenesis

CKR-5 CRISPR/Cas9 KO Plasmid (h) - sc-402548 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CKR-5 HDR Plasmid (h) - sc-402548-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CKR-5 Double Nickase Plasmid (h) - sc-402548-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CKR-5 Double Nickase Plasmid (h2) - sc-402548-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CKR-5 CRISPR Activation Plasmid (h) - sc-402548-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CKR-5 CRISPR Activation Plasmid (h2) - sc-402548-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CKR-5 Lentiviral Activation Particles (h) - sc-402548-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CKR-5 Lentiviral Activation Particles (h2) - sc-402548-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CKR-5 siRNA (h) - sc-35062 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CKR-5 shRNA Plasmid (h) - sc-35062-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CKR-5 shRNA (h) Lentiviral Particles - sc-35062-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU126851 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1164 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1164 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11206 from Sigma-Aldrich

Category miRNA

CCR5 siRNA (Human) - CRH0870 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CCR5 - MBS8234514 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CCR5 (NM_000579.3) - SHH258181 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CCR5(NM_000579.3) - SHG153631 from Creative biogene

Category siRNA
Species Reactivities Human

Human CCR5 siRNA - orb261372 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CCR5 shRNA Plasmid (Human) - CHH0870 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CCR5 miRNA 3'UTR clone - MiUTR1H-01827 from Creative biogene

Species Reactivities Human
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