| Gene Symbol | GPM6B |
|---|---|
| Entrez Gene | 2824 |
| Alt Symbol | M6B |
| Species | Human |
| Gene Type | protein-coding |
| Description | glycoprotein M6B |
| Other Description | neuronal membrane glycoprotein M6-b|protolipid M6B |
| Swissprots | Q8N956 Q86X43 O76077 Q13491 |
| Accessions | AAC19165 AAC19166 AAD13718 EAW98842 EAW98843 EAW98844 EAW98845 EAW98846 EAW98847 EAW98848 EAW98849 EAW98850 Q13491 AA991690 AB209525 BAD92762 AK095657 BAC04600 AK127103 AK294314 BAH11734 AK299675 BAH13099 AL119977 AM392527 CAL37405 AM392611 CAL37489 AM392700 CAL37578 AM392754 CAL37632 AM392864 CAL37742 AM392867 CAL37745 AM392943 CAL37821 AM392957 CAL37835 AM392968 CAL37846 AM392974 CAL37852 AM393048 CAL37926 AM393215 CAL38093 AM393570 CAL38447 AM393576 CAL38453 AM393741 CAL38616 AM393770 CAL38645 AM393783 CAL38658 AM393822 CAL38697 BC008151 AAH08151 BC047295 AAH47295 BF525674 BG532134 BI548345 BI599457 BI669888 DQ891541 ABM82467 DQ894729 ABM85655 EU832134 ACE87484 EU832227 ACE86797 U45955 AAB16888 XM_005274489 XP_005274546 XM_005274490 XP_005274547 XM_011545497 XP_011543799 NM_001001994 NP_001001994 NM_001001995 NP_001001995 NM_001001996 NP_001001996 NM_005278 NP_005269 |
| Function | May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. {ECO:0000269|PubMed:21638316}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with SERT at the plasma membrane. {ECO:0000250}. |
| Tissue Specificity | Neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia. |
M6B CRISPR/Cas9 KO Plasmid (h) - sc-410800 from Santa Cruz Biotechnology
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M6B HDR Plasmid (h) - sc-410800-HDR from Santa Cruz Biotechnology
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M6B Double Nickase Plasmid (h) - sc-410800-NIC from Santa Cruz Biotechnology
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M6B Double Nickase Plasmid (h2) - sc-410800-NIC-2 from Santa Cruz Biotechnology
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M6B CRISPR Activation Plasmid (h) - sc-410800-ACT from Santa Cruz Biotechnology
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M6B CRISPR Activation Plasmid (h2) - sc-410800-ACT-2 from Santa Cruz Biotechnology
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M6B Lentiviral Activation Particles (h) - sc-410800-LAC from Santa Cruz Biotechnology
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M6B Lentiviral Activation Particles (h2) - sc-410800-LAC-2 from Santa Cruz Biotechnology
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M6B siRNA (h) - sc-90853 from Santa Cruz Biotechnology
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M6B shRNA Plasmid (h) - sc-90853-SH from Santa Cruz Biotechnology
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M6B shRNA (h) Lentiviral Particles - sc-90853-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU080101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9533 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9533 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05198 from Sigma-Aldrich
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GPM6B siRNA (Human) - CRH1889 from Cohesion Biosciences
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GPM6B - MBS8232806 from MyBioSource
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shRNA set against Human GPM6B (NM_005278.3) - SHH305962 from Creative biogene
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shRNA set against Human GPM6B(NM_001001995.1) - SHH096671 from Creative biogene
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shRNA set against Human GPM6B(NM_001001994.1) - SHH096679 from Creative biogene
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shRNA set against Human GPM6B(NM_001001995.1) - SHH096697 from Creative biogene
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shRNA set against Human GPM6B(NM_005278.3) - SHH096707 from Creative biogene
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shRNA set against Human GPM6B(NM_001001996.1) - SHH096743 from Creative biogene
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GPM6B shRNA Plasmid (Human) - CHH1889 from Cohesion Biosciences
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GPM6B miRNA 3'UTR clone - MiUTR1H-04165 from Creative biogene
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