| Gene Symbol |
Htr1a
|
| Entrez Gene |
15550
|
| Alt Symbol |
Gpcr18
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
5-hydroxytryptamine (serotonin) receptor 1A
|
| Other Description |
5-HT-1A|5-HT1A receptor|5-hydroxytryptamine receptor 1A|G-protein coupled receptor 18|serotonin receptor 1A
|
| Swissprots |
Q61617 Q64264 Q8BGS4 Q60956
|
| Accessions |
AAC52572 AAK50428 EDL18479 Q64264 AK034017 BAC28548 AK043668 BAC31611 AK049814 BAC33931 AK049884 BAC33970 AK140194 BAE24273 BC138669 AAI38670 BC138681 AAI38682 BY239730 BY601671 L20339 AAA16850 U39391 AAA81519 NM_008308 NP_032334
|
| Function |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:11080
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:8254366}; Multi-pass membrane protein {ECO:0000269|PubMed:8254366}.
|
| Tissue Specificity |
Most abundantly expressed in midbrain, in dorsal raphe and hippocampus. Detected at lower levels in amygdala and brain cortex. {ECO:0000269|PubMed:9826725}.
|
| Top Pathways |
cAMP signaling pathway, Neuroactive ligand-receptor interaction
|