| Gene Symbol | CEP63 |
|---|---|
| Entrez Gene | 80254 |
| Alt Symbol | SCKL6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | centrosomal protein 63kDa |
| Other Description | centrosomal protein of 63 kDa|centrosome protein CEP63 |
| Swissprots | Q9H8N0 Q96MT8 Q96CR0 D3DNE0 D3DND8 Q9H8F5 D3DND9 |
| Accessions | EAW79136 EAW79137 EAW79138 EAW79139 EAW79140 EAW79141 EAW79142 Q96MT8 AA746981 AF113697 AK023448 BAB14578 AK023738 BAB14662 AK054897 AK056465 BAB71192 AK123837 BC014050 AAH14050 BC068997 AAH68997 BG182631 BI561425 BK005503 DAA05503 BX499930 CX751767 DB011963 HQ447283 ADQ31770 N36992 XM_005247795 XP_005247852 XM_005247797 XP_005247854 XM_005247799 XP_005247856 XM_006713760 XP_006713823 XM_011513193 XP_011511495 XM_011513194 XP_011511496 XM_011513195 XP_011511497 XM_011513196 XP_011511498 XM_011513197 XP_011511499 XM_011513198 XP_011511500 XM_011513199 XP_011511501 XM_011513200 XP_011511502 XM_011513201 XP_011511503 XM_011513202 XP_011511504 XM_011513203 XP_011511505 XM_011513204 XP_011511506 NM_001042383 NP_001035842 NM_001042384 NP_001035843 NM_001042400 NP_001035859 NM_025180 NP_079456 |
| Function | Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication, through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression. {ECO:0000269|PubMed:21406398, ECO:0000269|PubMed:21983783}. |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Colocalizes with CEP152 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. |