| Gene Symbol |
YTHDF2
|
| Entrez Gene |
51441
|
| Alt Symbol |
CAHL, HGRG8, NY-REN-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
YTH N(6)-methyladenosine RNA binding protein 2
|
| Other Description |
9430020E02Rik|CLL-associated antigen KW-14|YTH domain family, member 2|YTH domain-containing family protein 2|high-glucose-regulated protein 8|renal carcinoma antigen NY-REN-2
|
| Swissprots |
Q8TDH0 Q5VSZ9 B4E1G7 Q9Y5A9 Q9BUJ5 A6NKG4 D3DPM8 A8K966
|
| Accessions |
CAH05322 CAH05323 EAX07673 EAX07674 EAX07675 Q9Y5A9 AA603037 AB451335 BAG70149 AB451484 BAG70298 AF155095 AAD42861 AF192968 AAF08813 AF432214 AAL99921 AK074276 AK292581 BAF85270 AK303833 BAG64779 BC002559 AAH02559 BF792382 BP320783 DA697091 DC425394 DQ892157 ABM83083 DQ895352 ABM86278 NM_001172828 NP_001166299 NM_001173128 NP_001166599 NM_016258 NP_057342
|
| Function |
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation. {ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625}.
|
| Subcellular Location |
Cytoplasm, P-body {ECO:0000269|PubMed:24284625}.
|