MCM4

Gene Symbol	MCM4
Entrez Gene	856130
Alt Symbol	CDC54, HCD21
Species	Yeast
Gene Type	protein-coding
Description	MCM DNA helicase complex subunit MCM4
Other Description	-
Swissprots	D6W429 P30665
Accessions	DAA11445 P30665 NM_001184116 NP_015344
Function	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. Required for S phase execution. {ECO:0000269\|PubMed:19896182, ECO:0000269\|PubMed:19910535}.
Subcellular Location	Nucleus {ECO:0000250}.
Top Pathways	DNA replication, Cell cycle - yeast, Meiosis - yeast

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