MAPK14

Gene Symbol	MAPK14
Entrez Gene	1432
Alt Symbol	CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 14
Other Description	CSAID-binding protein|Csaids binding protein|MAP kinase 14|MAP kinase Mxi2|MAP kinase p38 alpha|MAX-interacting protein 2|cytokine suppressive anti-inflammatory drug binding protein|cytokine suppressive anti-inflammatory drug-binding protein|mitogen-activated protein kinase p38 alpha|p38 MAP kinase|p38 mitogen activated protein kinase|p38alpha Exip|stress-activated protein kinase 2A
Swissprots	Q8TDX0 Q16539 O60776 A8K6P4 B5TY32 A6ZJ92 B0LPH0 Q13083 Q14084
Accessions	AAC50329 ABY87549 AGC09599 EAX03867 EAX03868 EAX03869 EAX03870 EAX03871 EAX03872 EAX03873 Q16539 AB074150 BAB85654 AF100544 AAF36770 AK291709 BAF84398 AK303414 BAG64467 BC000092 AAH00092 BC031574 AAH31574 BT006933 AAP35579 CR536505 CAG38743 DA438432 FJ032367 ACI00233 FJ032368 ACI00234 L35263 AAA57455 L35264 AAA57456 Z25432 CAA80919 XM_006714998 XP_006715061 XM_011514310 XP_011512612 XM_011514311 XP_011512613 XR_926065 XR_926067 XR_926068 NM_001315 NP_001306 NM_139012 NP_620581 NM_139013 NP_620582 NM_139014 NP_620583
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mito
Subcellular Location	Cytoplasm. Nucleus.
Tissue Specificity	Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
Top Pathways	VEGF signaling pathway, Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Retrograde endocannabinoid signaling, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human p38 full length protein - ab82188 from Abcam Category Protein Prices $275.00 Sizes 10 µg Source E. coli Species Human

Human p38 (phospho T180 + Y182) peptide - ab58397 from Abcam Category Peptide

Human p38 full length protein - ab95445 from Abcam Category Protein Source E. coli Species Human

Human p38 full length protein - ab177254 from Abcam Category Protein Source E. coli Species Human

Human p38 full length protein - ab83503 from Abcam Category Protein Source Baculovirus Species Human

Human p38 full length protein - ab45157 from Abcam Category Protein Source E. coli Species Human

Human p38 full length protein - ab45158 from Abcam Category Protein Source E. coli Species Human

Human p38 peptide - ab58398 from Abcam Category Peptide

p38 peptide - ab7994 from Abcam Category Peptide

p38 peptide - ab53314 from Abcam Category Peptide

MAPK14 / p38 Antibody Blocking Peptide - LS-E4002 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK14 / p38 Antibody Blocking Peptide - LS-E10600 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK14 / p38 Antibody Blocking Peptide - LS-E8782 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK14 / p38 Antibody Blocking Peptide - LS-E8781 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK14 / p38 Antibody Blocking Peptide - LS-E7379 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

p38 Recombinant Protein - H00001432-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

p38 Recombinant Protein - P4239 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

p38 Recombinant Protein - H00001432-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

p38 Partial Recombinant Protein - H00001432-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

p38 Partial Recombinant Protein - H00001432-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

p38 Recombinant Protein - P4736 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

p38 Protein - NBP1-99509 from Novus Biologicals Category Protein Prices $309.00 Sizes 5 µg

Recombinant Human p38 Protein - NBP1-72539 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 100 µg, 500 µg Source E. coli Species Human

p38 Peptide - P2396 from Novus Biologicals Category Peptide Species Human

p38 Peptide - P2395 from Novus Biologicals Category Peptide Species Human

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