| Gene Symbol | MOGAT3 |
|---|---|
| Entrez Gene | 346606 |
| Alt Symbol | DC7, DGAT2L7, MGAT3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | monoacylglycerol O-acyltransferase 3 |
| Other Description | 2-acylglycerol O-acyltransferase 3|acyl coenzyme A:monoacylglycerol acyltransferase 3|acyl-CoA:monoacylglycerol acyltransferase 3|diacylglycerol O-acyltransferase candidate 7|diacylglycerol acyltransferase 2-like protein 7 |
| Swissprots | Q496A8 Q496A6 Q9UDW7 Q496A7 Q86VF5 |
| Accessions | AAD45832 CBF67541 CBF90900 CBU92414 CBV04420 EAW50203 EAW50204 Q86VF5 AY229854 AAO63579 AY358200 AAQ88567 BC100953 AAI00954 BC100954 AAI00955 BC100955 AAI00956 BE042458 XM_005250309 XP_005250366 XM_011516126 XP_011514428 XM_011516127 XP_011514429 NM_001287147 NP_001274076 NM_178176 NP_835470 |
| Function | Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. {ECO:0000269|PubMed:12618427}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Selectively expressed in the digestive system. Highly expressed in the ileum, and at lower level in jejunum, duodenum, colon, cecum and the rectum. Not expressed in the stomach and the esophagus and trachea. Expressed at very low level in liver. {ECO:0000269|PubMed:12618427}. |
| Top Pathways | Fat digestion and absorption, Glycerolipid metabolism |
MGAT3 CRISPR/Cas9 KO Plasmid (h) - sc-415617 from Santa Cruz Biotechnology
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MGAT3 HDR Plasmid (h) - sc-415617-HDR from Santa Cruz Biotechnology
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MGAT3 Double Nickase Plasmid (h) - sc-415617-NIC from Santa Cruz Biotechnology
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MGAT3 Double Nickase Plasmid (h2) - sc-415617-NIC-2 from Santa Cruz Biotechnology
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MGAT3 CRISPR Activation Plasmid (h) - sc-415617-ACT from Santa Cruz Biotechnology
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MGAT3 CRISPR Activation Plasmid (h2) - sc-415617-ACT-2 from Santa Cruz Biotechnology
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MGAT3 Lentiviral Activation Particles (h) - sc-415617-LAC from Santa Cruz Biotechnology
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MGAT3 Lentiviral Activation Particles (h2) - sc-415617-LAC-2 from Santa Cruz Biotechnology
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MGAT3 siRNA (h) - sc-44469 from Santa Cruz Biotechnology
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MGAT3 shRNA Plasmid (h) - sc-44469-SH from Santa Cruz Biotechnology
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MGAT3 shRNA (h) Lentiviral Particles - sc-44469-V from Santa Cruz Biotechnology
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MOGAT3 RNAi - H00346606-R01 from Novus Biologicals
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MISSION® esiRNA - EHU012791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14465 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14465 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00494 from Sigma-Aldrich
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MOGAT3 siRNA (Human) - CRJ7486 from Cohesion Biosciences
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shRNA set against Human MOGAT3 (NM_178176.2) - SHH343440 from Creative biogene
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MGAT3 CRISPR/Cas9 KO Plasmid (h2) - sc-415617-KO-2 from Santa Cruz Biotechnology
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MGAT3 HDR Plasmid (h2) - sc-415617-HDR-2 from Santa Cruz Biotechnology
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Human MOGAT3 siRNA - orb277987 from Biorbyt
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MOGAT3 shRNA Plasmid (Human) - CHJ7486 from Cohesion Biosciences
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MOGAT3 miRNA 3'UTR clone - MiUTR1H-06380 from Creative biogene
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