Diap1

Gene Symbol Diap1
Entrez Gene 13367
Alt Symbol D18Wsu154e, Dia1, Diaph1, Drf1, p140mDia
Species Mouse
Gene Type protein-coding
Description diaphanous homolog 1 (Drosophila)
Other Description diaphanous-related formin-1|protein diaphanous homolog 1
Swissprots O08808
Accessions EDL10115 EDL10116 EDL10117 O08808 AK012707 BAB28425 AK135915 BAE22723 AK140734 BAE24459 AK156391 BAE33697 AK220466 BAD90493 BC012974 BC021396 AAH21396 BC024979 BC029331 BC070412 AAH70412 U96963 AAC53280 XM_006525589 XP_006525652 XM_011246826 XP_011245128 NM_001305980 NP_001292909 NM_001305981 NP_001292910 NM_007858 NP_031884
Function Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration. Has neurite outgrowth promoting activity. The MEMO1- RHOA-DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stab
Subcellular Location Cell membrane {ECO:0000269|PubMed:9214622}. Cell projection, ruffle membrane {ECO:0000269|PubMed:9214622}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9214622}. Note=Membrane ruffles, especially at the tip of ruffles, of motile cells.
Tissue Specificity Ubiquitous.
Top Pathways Focal adhesion, Regulation of actin cytoskeleton

Dia 1 CRISPR/Cas9 KO Plasmid (m) - sc-420000 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dia 1 HDR Plasmid (m) - sc-420000-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dia 1 Double Nickase Plasmid (m) - sc-420000-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dia 1 Double Nickase Plasmid (m2) - sc-420000-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dia 1 CRISPR Activation Plasmid (m) - sc-420000-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dia 1 CRISPR Activation Plasmid (m2) - sc-420000-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dia 1 Lentiviral Activation Particles (m) - sc-420000-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dia 1 Lentiviral Activation Particles (m2) - sc-420000-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dia 1 siRNA (m) - sc-35191 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Dia 1 shRNA Plasmid (m) - sc-35191-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Dia 1 shRNA (m) Lentiviral Particles - sc-35191-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CompoZr® Knockout ZFN Kit - CKOZFN29991 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29991 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DIAPH1 siRNA (Mouse) - CRM1027 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

DIAPH1 - MBS8238670 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse Diap1 (NM_007858.2) - SHH278017 from Creative biogene

Category siRNA
Species Reactivities Mouse

DIAPH1 shRNA Plasmid (Mouse) - CHM1027 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

DIAP1 miRNA 3'UTR clone - MiUTR1M-03860 from Creative biogene

Species Reactivities Mouse
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