| Gene Symbol | CECR1 |
|---|---|
| Entrez Gene | 51816 |
| Alt Symbol | ADA2, ADGF, IDGFL, PAN, SNEDS |
| Species | Human |
| Gene Type | protein-coding |
| Description | cat eye syndrome chromosome region, candidate 1 |
| Other Description | adenosine deaminase 2|adenosine deaminase CECR1|cat eye syndrome critical region protein 1 |
| Swissprots | Q6ICF1 A8K9H4 Q9NZK5 Q96K41 Q8NCJ2 Q86UB6 |
| Accessions | EAW57750 EAW57751 Q9NZK5 AB209648 BAD92885 AF190746 AAF65941 AI523928 AK027682 BAB55293 AK074702 BAC11148 AK130725 AK292689 BAF85378 AK295174 BAG58184 AK304818 BAG65566 AK314321 BAG36969 BC051755 AAH51755 BX111961 CD369524 CR456417 CAG30303 CU012978 CAK54409 CU013266 CAK54708 DA864284 DB130953 DB286859 DC391616 EU446517 ABZ92046 XM_006724080 XP_006724143 XM_011546133 XP_011544435 NM_001282225 NP_001269154 NM_001282226 NP_001269155 NM_001282227 NP_001269156 NM_001282228 NP_001269157 NM_001282229 NP_001269158 NM_177405 NP_803124 NM_017424 |
| Function | Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. {ECO:0000269|PubMed:20147294, ECO:0000269|PubMed:20453107}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:15926889, ECO:0000269|PubMed:20147294, ECO:0000269|PubMed:20453107}. |
| Tissue Specificity | Detected in blood plasma (at protein level). Widely expressed, with most abundant expression in human adult heart, lung, lymphoblasts, and placenta as well as fetal lung, liver, and kidney. In embryo, expressed in the outflow tract and atrium of the developing heart, the VII/VIII cranial nerve ganglion, and the notochord. {ECO:0000269|PubMed:15926889}. |
CECR1 CRISPR/Cas9 KO Plasmid (h) - sc-407455 from Santa Cruz Biotechnology
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CECR1 HDR Plasmid (h) - sc-407455-HDR from Santa Cruz Biotechnology
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CECR1 Double Nickase Plasmid (h) - sc-407455-NIC from Santa Cruz Biotechnology
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CECR1 Double Nickase Plasmid (h2) - sc-407455-NIC-2 from Santa Cruz Biotechnology
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CECR1 CRISPR Activation Plasmid (h) - sc-407455-ACT from Santa Cruz Biotechnology
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CECR1 CRISPR Activation Plasmid (h2) - sc-407455-ACT-2 from Santa Cruz Biotechnology
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CECR1 Lentiviral Activation Particles (h) - sc-407455-LAC from Santa Cruz Biotechnology
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CECR1 Lentiviral Activation Particles (h2) - sc-407455-LAC-2 from Santa Cruz Biotechnology
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CECR1 siRNA (h) - sc-72854 from Santa Cruz Biotechnology
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CECR1 shRNA Plasmid (h) - sc-72854-SH from Santa Cruz Biotechnology
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CECR1 shRNA (h) Lentiviral Particles - sc-72854-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU078101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5915 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5915 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12868 from Sigma-Aldrich
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CECR1 siRNA (Human) - CRH9955 from Cohesion Biosciences
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CECR1 - MBS8234950 from MyBioSource
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shRNA set against Human CECR1 (NM_177405.1) - SHH261381 from Creative biogene
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shRNA set against Human CECR1(NM_017424.2) - SHG143613 from Creative biogene
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CECR1 shRNA Plasmid (Human) - CHH9955 from Cohesion Biosciences
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CECR1 miRNA 3'UTR clone - MiUTR1H-02025 from Creative biogene
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CECR1 miRNA 3'UTR clone - MiUTR1H-02026 from Creative biogene
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