| Gene Symbol |
HOPX
|
| Entrez Gene |
396692
|
| Alt Symbol |
OB1
|
| Species |
Pig
|
| Gene Type |
protein-coding
|
| Description |
HOP homeobox
|
| Other Description |
homeodomain-only protein|odd homeobox 1 protein|odd homeobox protein 1
|
| Swissprots |
Q8MJD6
|
| Accessions |
Q8MJD6 AF492682 AAM46834 AK231735 AK346408 XM_005666682 XP_005666739 XM_005666683 XP_005666740 XM_005666684 XP_005666741 XM_005666685 XP_005666742 XM_005666686 XP_005666743 XM_005666687 XP_005666744 XM_005666688 XP_005666745 XM_005666689 XP_005666746 NM_213792 NP_998957
|
| Function |
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
|