| Gene Symbol | HOPX |
|---|---|
| Entrez Gene | 396692 |
| Alt Symbol | OB1 |
| Species | Pig |
| Gene Type | protein-coding |
| Description | HOP homeobox |
| Other Description | homeodomain-only protein|odd homeobox 1 protein|odd homeobox protein 1 |
| Swissprots | Q8MJD6 |
| Accessions | Q8MJD6 AF492682 AAM46834 AK231735 AK346408 XM_005666682 XP_005666739 XM_005666683 XP_005666740 XM_005666684 XP_005666741 XM_005666685 XP_005666742 XM_005666686 XP_005666743 XM_005666687 XP_005666744 XM_005666688 XP_005666745 XM_005666689 XP_005666746 NM_213792 NP_998957 |
| Function | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}. |