| Gene Symbol |
RPSA
|
| Entrez Gene |
281898
|
| Alt Symbol |
LAMR1
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
ribosomal protein SA
|
| Other Description |
37 kDa laminin receptor|37/67 kDa laminin receptor|37LRP|40S ribosomal protein SA|67 kDa laminin receptor|67LR|LBP/p40|LRP/LR|lamR|laminin receptor 1 (ribosomal protein SA, 67 kDA)|laminin-binding protein precursor p40|ribosomal protein SA pseudogene
|
| Swissprots |
P26452 Q3ZCE4
|
| Accessions |
DAA17125 P26452 AB098757 AB098775 AB098943 BAC56433 AB099011 BAC56501 BC102490 AAI02491 JF979129 AEI70329 M64923 AAA62713 XM_005222369 XP_005222426 XM_005222370 XP_005222427 NM_174379 NP_776804
|
| Function |
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP-Rule:MF_03016}.
|
| Subcellular Location |
Cell membrane {ECO:0000255|HAMAP- Rule:MF_03016}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:1849001}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Colocalizes with PPP1R16B in the cell membrane (By similarity). {ECO:0000255|HAMAP-Rule:MF_03016}.
|
| Top Pathways |
Ribosome
|