| Gene Symbol | KIZ |
|---|---|
| Entrez Gene | 55857 |
| Alt Symbol | C20orf19, HT013, Kizuna, NCRNA00153, PLK1S1, RP69 |
| Species | Human |
| Gene Type | protein-coding |
| Description | kizuna centrosomal protein |
| Other Description | centrosomal protein kizuna|polo-like kinase 1 substrate 1 |
| Swissprots | Q71ME0 Q4G0S5 B4DK54 Q5BKY3 Q9NZ35 Q2M2Z5 Q4G0M8 B4DDE9 Q6P0M6 |
| Accessions | EAX10188 EAX10189 EAX10190 EAX10191 EAX10192 EAX10193 Q2M2Z5 AF220187 AAF67652 AF451990 AAP97689 AK025476 AK055105 AK293166 BAG56710 AK293567 BAG57038 AK295355 BAG58321 AK296399 BAG59066 AL110196 CAH10726 BC013055 BC039296 AAH39296 BC045826 AAH45826 BC065550 AAH65550 BC090879 AAH90879 BC105093 AAI05094 BC113370 AAI13371 DC386700 XM_011529296 XP_011527598 XM_011529297 XP_011527599 XM_011529298 XP_011527600 XM_011529299 XP_011527601 XR_937105 NM_001163022 NP_001156494 NM_001163023 NP_001156495 NM_001276389 NP_001263318 NM_018474 NP_060944 |
| Function | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16980960}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24680887}. Note=Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome-surrounding area in a microtubule-independent and dependent manner, respectively. {ECO:0000269|PubMed:24680887}. |