PLCG2

Gene Symbol PLCG2
Entrez Gene 5336
Alt Symbol APLAID, FCAS3, PLC-IV, PLC-gamma-2
Species Human
Gene Type protein-coding
Description phospholipase C, gamma 2 (phosphatidylinositol-specific)
Other Description 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2|phosphoinositide phospholipase C-gamma-2|phospholipase C-IV
Swissprots Q3ZTS2 Q59H45 Q969T5 D3DUL3 P16885
Accessions AAA78806 EAW95524 EAW95525 EAW95526 P16885 AB208914 BAD92151 AK127374 AK304722 BAG65485 AK310042 AW504432 AY364256 AAQ76815 BC007565 AAH07565 BC011772 AAH11772 BC014561 AAH14561 BC018646 AAH18646 BC018983 BC040927 BP351485 BX504887 DB456860 DQ893524 ABM84450 DQ896514 ABM87513 HG508362 M37238 AAA60112 X14034 CAA32194 XM_011523108 XP_011521410 NM_002661 NP_002652
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Top Pathways MicroRNAs in cancer, Epstein-Barr virus infection, Inflammatory mediator regulation of TRP channels, Osteoclast differentiation, Proteoglycans in cancer

Phospho-PLCγ2 (Tyr759) Antibody - 3874 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from untreated or anti-human IgM treated Ramos cells or lamda phosphatase-treated Ramos cell lysates, using Phospho-PLCgamma2 (Tyr759) Antibody (upper) or PLCgamma2 Antibody #3872 (lower).

Phospho-PLCγ2 (Tyr1217) Antibody - 3871 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Ramos cells, untreated or treated with anti-human IgM, using Phospho-PLCgamma2 (Tyr1217) Antibody (upper) or PLCgamma2 Antibody #3872 (lower).

PLCγ2 Antibody - 3872 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Ramos (lane 1), THP1 (lane 2), U-937 (lane 3) cells and mouse spleenocytes (lane 4), using PLCγ2 Antibody.

PLC γ2 (B-10) - sc-5283 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PLC γ2 (B-10): sc-5283. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lymphoma showing membrane and cytoplasmic staining (A). Immunofluorescence staining of methanol-fixed U-937 cells showing cytoplasmic staining (B).

PLC γ2 (A-3) - sc-390389 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PLC γ2 (A-3): sc-390389. Western blot analysis of PLC γ2 expression in non-transfected 293T: sc-117752 (A), human PLC γ2 transfected 293T: sc-172701 (B), Ramos (C) and THP-1 (D) whole cell lysates.

PLC γ2 (K-18) - sc-31752 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PLC γ2 (K-18): sc-31752. Western blot analysis of PLC γ2 expression in GA-10 (A) and Ramos (B) whole cell lysates.

PLC γ2 (H-160) - sc-9015 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PLC γ2 (H-160): sc-9015. Western blot analysis of PLC γ2 expression in Ramos whole cell lysate.

PLC γ2 (N-17) - sc-31751 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PLC γ2 (N-17): sc-31751. Western blot analysis of PLC γ2 expression in Ramos whole cell lysate.

PLC γ2 (Q-20) - sc-407 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PLCγ2 (Q-20): sc-407. Western blot analysis of PLC γ2 expression in MCF7 (A), MCF7 + etoposide (B), U-937 (C) and THP-1 (D) whole cell lysates.

p-PLC γ2 (Tyr 753) - sc-101785 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-PLC γ2 (Tyr 753): sc-101785. Western blot analysis of phosphorylated PLC γ2 expression in untreated (A) and EGF-treated (B) A-431 whole cell lysates.

Anti-PLCG 2 (phospho Y1197) antibody [EP1405Y] - ab75970 from Abcam

Prices $99.00, $357.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1405Y
All lanes : Anti-PLCG 2 (phospho Y1197) antibody [EP1405Y] (ab75970) at 1/20000 dilutionLane 1 : Raji cell lysates un-treatedLane 2 : Raji cell lysates treated with pervanadateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-PLCG 2 (phospho Y1217) antibody - ab194913 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue labeling PLCG 2 (phospho Y1217) with ab194913 at 1/50 dilution.

Anti-PLCG 2 (phospho Y1217) antibody [EP1404Y] - ab52610 from Abcam

Prices $99.00, $379.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1404Y
All lanes : Anti-PLCG 2 (phospho Y1217) antibody [EP1404Y] (ab52610) at 1/50000 dilutionLane 1 : Raji cell lysate with no pervanadateLane 2 : Raji cell lysate with pervanadateLysates/proteins at 10 µg per lane.SecondaryHRP-labelled goat anti-rabbit at 1/2000 dilution

Anti-PLCG 2 (phospho Y753) antibody - ab192221 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PLCG 2 (phospho Y753) antibody (ab192221) at 1/500 dilutionLane 1 : HepG2 whole cell lysate with antigen-specific peptideLane 2 : HepG2 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-PLCG 2 (phospho Y753) antibody [3A8B6] - ab201969 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3A8B6
Flow cytometric analysis of HeLa cells labeling PLCG 2 (phospho Y753) with ab201969 at 1/200 dilution (green). Negative control (red).

Anti-PLCG 2 (phospho Y753) antibody [EPR5914] - ab133455 from Abcam

Prices $99.00, $313.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5914
All lanes : Anti-PLCG 2 (phospho Y753) antibody [EPR5914] (ab133455) at 1/50000 dilutionLane 1 : Raji cell lysateLane 2 : Raji cell lysate treated with PervanadateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit IgG at 1/2000 dilution

Anti-PLCG 2 (phospho Y753) antibody [MM0873-19S8] - ab201642 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0873-19S8

Anti-PLCG 2 (phospho Y759) antibody [EP1406Y] - ab51020 from Abcam

Prices $99.00, $379.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1406Y
All lanes : Anti-PLCG 2 (phospho Y759) antibody [EP1406Y] (ab51020) at 1/100000 dilutionLane 1 : Raji cell lysate, untreatedLane 2 : Raji cell lysate, treated with pervanadateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP labeled at 1/2000 dilution

Anti-PLCG 2 (phospho Y759) antibody [MM0872-27K18] - ab201617 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0872-27K18

Anti-PLCG 2 antibody - ab154216 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PLCG 2 antibody (ab154216) at 1/1000 dilution + Raji whole cell lysate at 30 µg

Anti-PLCG 2 antibody [EP1402Y] - ab62365 from Abcam

Prices $99.00, $379.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1402Y
Anti-PLCG 2 antibody [EP1402Y] (ab62365) at 1/2000 dilution + Ramos cell lysate at 10 µgSecondarygoat anti-rabbit, HRP labeled, at 1/2000 dilution

Anti-PLCG 2 antibody [EPR1403] - ab109267 from Abcam

Prices $99.00, $379.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1403
All lanes : Anti-PLCG 2 antibody [EPR1403] (ab109267) at 1/1000 dilutionLane 1 : Ramos cell lysateLane 2 : Raji cell lysateLysates/proteins at 10 µg per lane.

Anti-PLCG 2 antibody [EPR5914] - ab133522 from Abcam

Prices $99.00, $385.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5914
All lanes : Anti-PLCG 2 antibody [EPR5914] (ab133522) at 1/10000 dilutionLane 1 : Raji cell lysatesLane 2 : Ramos cell lysatesLysates/proteins at 10 µg per lane.SecondaryHRP-labelled Goat anti-Rabbit at 1/2000 dilution

Anti-PLCG 2 antibody [MM087134S3] - ab201645 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM087134S3

Anti-PLCG 2 (phospho Y1217) antibody - ab59221 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab59221 (1/100 dilution) staining PLCG 2 in human brain tissue by Immunohistochemistry (Paraffin section); in the absence or presence of the immunising peptide.
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