| Gene Symbol | PLCG2 |
|---|---|
| Entrez Gene | 5336 |
| Alt Symbol | APLAID, FCAS3, PLC-IV, PLC-gamma-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phospholipase C, gamma 2 (phosphatidylinositol-specific) |
| Other Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2|phosphoinositide phospholipase C-gamma-2|phospholipase C-IV |
| Swissprots | Q3ZTS2 Q59H45 Q969T5 D3DUL3 P16885 |
| Accessions | AAA78806 EAW95524 EAW95525 EAW95526 P16885 AB208914 BAD92151 AK127374 AK304722 BAG65485 AK310042 AW504432 AY364256 AAQ76815 BC007565 AAH07565 BC011772 AAH11772 BC014561 AAH14561 BC018646 AAH18646 BC018983 BC040927 BP351485 BX504887 DB456860 DQ893524 ABM84450 DQ896514 ABM87513 HG508362 M37238 AAA60112 X14034 CAA32194 XM_011523108 XP_011521410 NM_002661 NP_002652 |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. |
| Top Pathways | MicroRNAs in cancer, Epstein-Barr virus infection, Inflammatory mediator regulation of TRP channels, Osteoclast differentiation, Proteoglycans in cancer |