Gene Symbol | Hyal2 |
---|---|
Entrez Gene | 15587 |
Alt Symbol | AI256841, AU020858, AW555733 |
Species | Mouse |
Gene Type | protein-coding |
Description | hyaluronoglucosaminidase 2 |
Other Description | hyal-2|hyaluronidase 2|hyaluronidase-2|hyaluronoglucosaminidase-2 |
Swissprots | Q99MT0 Q99MS9 O35631 O35632 |
Accessions | CAA03889 EDL21201 EDL21202 O35632 AF302843 AAK28481 AF302844 AAK28482 AF422177 AAL17823 AF535140 AAO49503 AJ000059 CAA03888 AK080146 AK087358 BAC39851 AK088806 BAC40583 AK133886 BAE21913 BC060047 XM_006511643 XP_006511706 XM_006511644 XP_006511707 XM_006511645 XP_006511708 NM_010489 NP_034619 |
Function | Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. |
Tissue Specificity | Widely expressed. In the brain, expressed during embryonic stages but expression decreases after birth and is barely detectable in adult brain. {ECO:0000269|PubMed:9790770}. |
Top Pathways | Glycosaminoglycan degradation |
HYAL2 CRISPR/Cas9 KO Plasmid (m) - sc-421009 from Santa Cruz Biotechnology
|
||||||||
HYAL2 HDR Plasmid (m) - sc-421009-HDR from Santa Cruz Biotechnology
|
||||||||
HYAL2 Double Nickase Plasmid (m) - sc-421009-NIC from Santa Cruz Biotechnology
|
||||||||
HYAL2 Double Nickase Plasmid (m2) - sc-421009-NIC-2 from Santa Cruz Biotechnology
|
||||||||
HYAL2 CRISPR Activation Plasmid (m) - sc-421009-ACT from Santa Cruz Biotechnology
|
||||||||
HYAL2 CRISPR Activation Plasmid (m2) - sc-421009-ACT-2 from Santa Cruz Biotechnology
|
||||||||
HYAL2 Lentiviral Activation Particles (m) - sc-421009-LAC from Santa Cruz Biotechnology
|
||||||||
HYAL2 Lentiviral Activation Particles (m2) - sc-421009-LAC-2 from Santa Cruz Biotechnology
|
||||||||
HYAL2 siRNA (m) - sc-60825 from Santa Cruz Biotechnology
|
||||||||
HYAL2 shRNA Plasmid (m) - sc-60825-SH from Santa Cruz Biotechnology
|
||||||||
HYAL2 shRNA (m) Lentiviral Particles - sc-60825-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EMU013161 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN33569 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33569 from Sigma-Aldrich
|
||||||||
HYAL2 siRNA (Mouse) - CRM1977 from Cohesion Biosciences
|
||||||||
HYAL2 - MBS8236631 from MyBioSource
|
||||||||
shRNA set against Mouse HYAL2 (NM_010489.2) - SHH316165 from Creative biogene
|
||||||||
shRNA set against Mouse Hyal2(NM_010489.2) - SHH136919 from Creative biogene
|
||||||||
Mouse HYAL2 siRNA - orb281453 from Biorbyt
|
||||||||
HYAL2 shRNA Plasmid (Mouse) - CHM1977 from Cohesion Biosciences
|
||||||||
HYAL2 miRNA 3'UTR clone - MiUTR1M-05863 from Creative biogene
|