| Gene Symbol |
GABRP
|
| Entrez Gene |
2568
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
gamma-aminobutyric acid (GABA) A receptor, pi
|
| Other Description |
GABA(A) receptor subunit pi|GABA(A) receptor, pi|gamma-aminobutyric acid receptor subunit pi
|
| Swissprots |
O00591 D3DQL2 A8KA36 Q32MJ1
|
| Accessions |
AAC24194 CAM83950 EAW61466 EAW61467 EAW61468 O00591 AK055205 BAG51486 AK292901 BAF85590 AK296805 BAG59378 AK300303 BAG62056 AL708685 BC074810 AAH74810 BC074865 AAH74865 BC109105 AAI09106 BC109106 AAI09107 DC346374 U95367 AAC51357 XM_005265872 XP_005265929 XM_011534502 XP_011532804 XM_011534503 XP_011532805 XM_011534504 XP_011532806 XM_011534505 XP_011532807 XM_011534506 XP_011532808 NM_001291985 NP_001278914 NM_014211 NP_055026
|
| Function |
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Most abundant in the uterus, also expressed in lung, thymus and prostate.
|
| Top Pathways |
GABAergic synapse, Morphine addiction, Nicotine addiction, Retrograde endocannabinoid signaling, Neuroactive ligand-receptor interaction
|