| Gene Symbol |
ATP11A
|
| Entrez Gene |
23250
|
| Alt Symbol |
ATPIH, ATPIS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATPase, class VI, type 11A
|
| Other Description |
P4-ATPase flippase complex alpha subunit ATP11A|phospholipid-translocating ATPase|potential phospholipid-transporting ATPase IH|probable phospholipid-transporting ATPase IH
|
| Swissprots |
P98196 Q5VXT2
|
| Accessions |
EAX09171 P98196 AB028944 BAA82973 AI703438 AK024264 AK025511 BAB15157 AK091253 AK128241 AL161996 CAH56364 BC008824 BC024154 AAH24154 BC035215 BC044649 BC167794 AAI67794 BE675783 XM_005268299 XP_005268356 XM_005268300 XP_005268357 XM_005268301 XP_005268358 XM_005268303 XP_005268360 XM_005268305 XP_005268362 XM_005268306 XP_005268363 XM_006719965 XP_006720028 XM_011537478 XP_011535780 XM_011537479 XP_011535781 XM_011537480 XP_011535782 XM_011537481 XP_011535783 XR_944275 NM_015205 NP_056020 NM_032189 NP_115565
|
| Function |
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. {ECO:0000269|PubMed:15860663, ECO:0000305}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:21914794}; Multi-pass membrane protein {ECO:0000269|PubMed:21914794}. Early endosome {ECO:0000269|PubMed:21914794}. Recycling endosome {ECO:0000269|PubMed:21914794}. Endoplasmic reticulum {ECO:0000269|PubMed:21914794}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane.
|