| Gene Symbol | ALDH1A3 |
|---|---|
| Entrez Gene | 220 |
| Alt Symbol | ALDH1A6, ALDH6, MCOP8, RALDH3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | aldehyde dehydrogenase 1 family, member A3 |
| Other Description | acetaldehyde dehydrogenase 6|aldehyde dehydrogenase 6|aldehyde dehydrogenase family 1 member A3|retinaldehyde dehydrogenase 3 |
| Swissprots | Q6NT64 P47895 |
| Accessions | EAX02281 EAX02282 EAX02283 P47895 AK056534 AK302607 BAG63855 AK303441 BAG64488 AK312303 BAG35229 AL110109 BC009245 BC069274 AAH69274 BC101605 AAI01606 BC117365 AAI17366 BX538027 CAD97973 DB480234 EU831943 ACE87384 EU832038 ACE86700 HG507539 HG507540 HG507541 U07919 AAA79036 NM_000693 NP_000684 NM_001293815 NP_001280744 NM_001037224 |
| Function | Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney. |
| Top Pathways | Chemical carcinogenesis, Glycolysis / Gluconeogenesis, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450, Tyrosine metabolism |