| Gene Symbol |
ZFPM2
|
| Entrez Gene |
23414
|
| Alt Symbol |
DIH3, FOG2, SRXY9, ZC2HC11B, ZNF89B, hFOG-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger protein, FOG family member 2
|
| Other Description |
FOG-2|Friend of GATA2|friend of GATA 2|friend of GATA protein 2|transcription factor GATA4, modulator of|zinc finger protein 89B|zinc finger protein ZFPM2|zinc finger protein, multitype 2
|
| Swissprots |
Q9NPL7 Q9UNI5 Q9NPS4 Q32MA6 Q8WW38
|
| Accessions |
EAW91899 Q8WW38 AB073894 AF119334 AAD49558 AK296997 BAG59535 AK303058 BAG64175 AK316426 BAH14797 AL389974 AL389987 CAB97539 AL389988 CAB97540 AL389989 CAB97541 BC020928 AAH20928 BC109222 AAI09223 BC109223 AAI09224 XM_011516946 XP_011515248 XM_011516947 XP_011515249 XM_011516948 XP_011515250 XM_011516949 XP_011515251 NM_012082 NP_036214
|
| Function |
Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:23226341}.
|
| Tissue Specificity |
Widely expressed at low level. {ECO:0000269|PubMed:10438528}.
|
| Top Pathways |
MicroRNAs in cancer
|