| Gene Symbol |
Aif1
|
| Entrez Gene |
11629
|
| Alt Symbol |
AI607846, AIF-1, D17H6S50E, G1, Iba1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
allograft inflammatory factor 1
|
| Other Description |
ionized calcium binding adapter molecule 1|ionized calcium-binding adapter molecule 1|testis specific
|
| Swissprots |
O70200
|
| Accessions |
AAC24189 AAC82481 BAB20757 BAB20758 CAD91187 EDL26636 EDL26637 O70200 AB013745 BAA28216 AF074959 AAC25604 AK006184 BAB24445 AK006562 BAB24654 BC021539 AAH21539 CT010265 CAJ18473 CT010385 CAJ18592 D86382 BAA86387 EF101555 ABK96804 XM_006523503 XP_006523566 XM_006523504 XP_006523567 XM_006525277 XP_006525340 XM_006525278 XP_006525341 XM_006536502 XP_006536565 XM_006536503 XP_006536566 XM_006537235 XP_006537298 XM_006537236 XP_006537299 NM_019467 NP_062340
|
| Function |
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. {ECO:0000269|PubMed:10934045, ECO:0000269|PubMed:11500035, ECO:0000269|PubMed:11722645, ECO:0000269|PubMed:11916959, ECO:0000269|PubMed:14756805}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
|
| Tissue Specificity |
Abundantly expressed in the testis, moderately in the spleen and lymph nodes and at low levels in the liver and thymus. Detected in macrophages. {ECO:0000269|PubMed:11722645}.
|