| Gene Symbol |
MAPK7
|
| Entrez Gene |
5598
|
| Alt Symbol |
BMK1, ERK4, ERK5, PRKM7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase 7
|
| Other Description |
BMK-1|BMK1 kinase|ERK-5|MAP kinase 7|MAPK 7|big MAP kinase 1|extracellular signal-regulated kinase 5|extracellular-signal-regulated kinase 5
|
| Swissprots |
Q6QLU7 Q59F50 Q7L4P4 Q96G51 Q16634 Q969G1 Q13164
|
| Accessions |
AAA82933 EAW50883 EAW50884 EAW50885 EAW50886 EAW50887 Q13164 AB209611 BAD92848 AK295376 BAG58335 AY534741 AAS38577 BC007404 AAH07404 BC007992 AAH07992 BC009963 AAH09963 BC030134 AAH30134 BP871947 DA452383 DB133227 HQ257997 ADR82751 U25278 AAA81381 U29725 AAA82931 U29726 AAA82932 XM_005256719 XP_005256776 XM_006721557 XP_006721620 XM_006721558 XP_006721621 XM_006721559 XP_006721622 XM_011523957 XP_011522259 NM_002749 NP_002740 NM_139032 NP_620601 NM_139033 NP_620602 NM_139034 NP_620603
|
| Function |
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation.
|
| Tissue Specificity |
Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver. {ECO:0000269|PubMed:7759517}.
|
| Top Pathways |
Gap junction, GnRH signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, MicroRNAs in cancer
|