| Gene Symbol |
Ttll7
|
| Entrez Gene |
70892
|
| Alt Symbol |
1110049N09Rik, 4921517B04Rik, C630030B20
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
tubulin tyrosine ligase-like family, member 7
|
| Other Description |
polyglutamylase|tubulin polyglutamylase TTLL7|tubulin--tyrosine ligase-like protein 7
|
| Swissprots |
A4Q9F0 Q8C417 Q9D5V3 A4Q9E9
|
| Accessions |
A4Q9F0 AK004213 AK014905 BAB29613 AK083236 BAC38821 AM690750 CAM84327 AM690751 CAM84328 BC138274 AAI38275 BC138275 AAI38276 BP758417 CJ110550 XM_006502087 XP_006502150 XM_006502088 XP_006502151 NM_027594 NM_001302957 NP_001289886 NM_001302958 NP_001289887
|
| Function |
Polyglutamylase which preferentially modifies beta- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Required for neurite growth. {ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:17499049}.
|
| Subcellular Location |
Cell projection, cilium {ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:17499049}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:17499049}. Cell projection, dendrite {ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:17499049}. Perikaryon {ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:17499049}. Note=In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon. {ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:17499049}.
|
| Tissue Specificity |
Widely expressed with highest levels in brain, testis and trachea. In brain, highly expressed in hippocampus, thalamus, olfactory bulb and cerebellum. {ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:17499049}.
|