| Gene Symbol | Htr1d |
|---|---|
| Entrez Gene | 15552 |
| Alt Symbol | 5-HT-1D, 5-HT1D, AI853647, Gpcr14, Htr1db |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | 5-hydroxytryptamine (serotonin) receptor 1D |
| Other Description | 5-hydroxytryptamine (serotonin) receptor 1D beta|5-hydroxytryptamine receptor 1D|G-protein coupled receptor 14|serotonin receptor 1D |
| Swissprots | Q61224 Q3ZB48 Q61615 Q8BUW7 |
| Accessions | AAB23261 CAA64395 EDL29938 EDL29939 Q61224 AI853647 AK082016 BAC38393 AW487918 BB832969 BC103532 AAI03533 BC103535 AAI03536 BC103536 AAI03537 BY728591 L20335 AAA16847 XM_006538577 XP_006538640 XM_006538578 XP_006538641 NM_001285482 NP_001272411 NM_001285483 NP_001272412 NM_001285484 NP_001272413 NM_008309 NP_032335 |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Detected in the motor column in spinal cord, and in several cranial motor nuclei, including nucleus ambiguous, oculomotoris, trochelaris and abducens. Detected in gamma motor neurons in the lumbar spinal cord. Detected in proprioceptive sensory neurons in dorsal root ganglia. {ECO:0000269|PubMed:22273508}. |
| Top Pathways | cAMP signaling pathway, Neuroactive ligand-receptor interaction |
SR-1D CRISPR/Cas9 KO Plasmid (m) - sc-420991 from Santa Cruz Biotechnology
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SR-1D HDR Plasmid (m) - sc-420991-HDR from Santa Cruz Biotechnology
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SR-1D Double Nickase Plasmid (m) - sc-420991-NIC from Santa Cruz Biotechnology
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SR-1D Double Nickase Plasmid (m2) - sc-420991-NIC-2 from Santa Cruz Biotechnology
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SR-1D CRISPR Activation Plasmid (m) - sc-420991-ACT from Santa Cruz Biotechnology
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SR-1D CRISPR Activation Plasmid (m2) - sc-420991-ACT-2 from Santa Cruz Biotechnology
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SR-1D Lentiviral Activation Particles (m) - sc-420991-LAC from Santa Cruz Biotechnology
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SR-1D Lentiviral Activation Particles (m2) - sc-420991-LAC-2 from Santa Cruz Biotechnology
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SR-1D siRNA (m) - sc-42226 from Santa Cruz Biotechnology
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SR-1D shRNA Plasmid (m) - sc-42226-SH from Santa Cruz Biotechnology
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SR-1D shRNA (m) Lentiviral Particles - sc-42226-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU075541 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33546 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33546 from Sigma-Aldrich
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HTR1D siRNA (Mouse) - CRM1960 from Cohesion Biosciences
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HTR1D - MBS8223539 from MyBioSource
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shRNA set against Mouse HTR1D (NM_008309.4) - SHH315892 from Creative biogene
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shRNA set against Mouse Htr1d(NM_008309.4) - SHH135533 from Creative biogene
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Mouse HTR1D siRNA - orb281436 from Biorbyt
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HTR1D shRNA Plasmid (Mouse) - CHM1960 from Cohesion Biosciences
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HTR1D miRNA 3'UTR clone - MiUTR1M-05844 from Creative biogene
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