| Gene Symbol |
CBLB
|
| Entrez Gene |
868
|
| Alt Symbol |
Cbl-b, Nbla00127, RNF56
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Cbl proto-oncogene B, E3 ubiquitin protein ligase
|
| Other Description |
Cas-Br-M (murine) ecotropic retroviral transforming sequence b|Cas-Br-M (murine) ectropic retroviral transforming sequence b|Cbl proto-oncogene, E3 ubiquitin protein ligase B|E3 ubiquitin-protein ligase CBL-B|RING finger protein 56|SH3-binding protein CBL-B|casitas B-lineage lymphoma proto-oncogene b|signal transduction protein CBL-B
|
| Swissprots |
Q13192 A8K9S7 Q63Z43 Q3LIC0 Q8IVC5 B7WNM4 Q13193 Q13191
|
| Accessions |
EAW79751 EAW79752 EAW79753 EAW79754 Q13191 AA251219 AB075490 BAE45748 AK094184 BAG52839 AK123147 BAG53874 AK130668 AK292792 BAF85481 AK302533 BAG63805 AK302892 BAG64066 AK316276 BAH14647 BC032851 AAH32851 BC065915 BQ188745 BX537484 CAH56175 BX649066 CR749655 CAH18449 DQ349203 ABC86700 DQ349204 ABC86701 DQ894452 ABM85378 EU176266 ABW03717 R78694 U26710 AAB09291 U26711 AAB09292 U26712 AAB09293 XM_005247853 XP_005247910 XM_011513257 XP_011511559 XM_011513258 XP_011511560 XM_011513259 XP_011511561 XR_924204 XR_924205 XR_924206 NM_170662 NP_733762
|
| Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:1
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12177062}. Note=Upon EGF stimulation, associates with endocytic vesicles.
|
| Tissue Specificity |
Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes (at protein level). {ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:9399639}.
|
| Top Pathways |
Proteoglycans in cancer, Ubiquitin mediated proteolysis, Measles, Bacterial invasion of epithelial cells, Endocytosis
|