| Gene Symbol |
SLCO1C1
|
| Entrez Gene |
53919
|
| Alt Symbol |
OATP-F, OATP1, OATP14, OATP1C1, OATPF, OATPRP5, SLC21A14
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier organic anion transporter family, member 1C1
|
| Other Description |
OAT-RP-5|OATP-14|organic anion transporter F|organic anion transporter polypeptide-related protein 5|organic anion transporting polypeptide 14|organic anion-transporting polypeptide 14|solute carrier family 21 (organic anion transporter), member 14|solute carrier family 21 member 14|solute carrier organic anion transporter family member 1C1|thyroxine transporter
|
| Swissprots |
Q5JPA4 B7Z3Q3 Q9NYB5 B7Z251 B7Z8P1 F5GZD6
|
| Accessions |
CAD67738 CAD67739 EAW96411 EAW96412 Q9NYB5 AF205076 AAG42208 AF260704 AAF70338 AK294333 BAH11737 AK296236 BAH12289 AK303713 BAH14027 AK308729 AL834209 CAI46209 BC022461 AAH22461 DA345251 EU176210 ABW03661 XM_005253394 XP_005253451 XM_005253396 XP_005253453 XM_005253397 XP_005253454 XM_011520703 XP_011519005 XM_011520704 XP_011519006 XM_011520705 XP_011519007 XM_011520706 XP_011519008 XM_011520707 XP_011519009 XM_011520708 XP_011519010 XM_011520709 XP_011519011 XM_011520710 XP_011519012 XM_011520711 XP_011519013 XM_011520712 XP_011519014 XM_011520713 XP_011519015 XR_931308 NM_001145944 NP_001139416 NM_001145945 NP_001139417 NM_001145946 NP_001139418 NM_017435 NP_059131
|
| Function |
Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000269|PubMed:18687783}. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels. {ECO:0000269|PubMed:18687783}.
|