| Gene Symbol | ADAMTSL4 |
|---|---|
| Entrez Gene | 54507 |
| Alt Symbol | ADAMTSL-4, ECTOL2, TSRC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ADAMTS-like 4 |
| Other Description | ADAMTS-like protein 4|thrombospondin repeat-containing protein 1 |
| Swissprots | Q6IPM6 F8WAD0 Q6UY14 Q9HBS6 Q8N643 Q5T5F7 B2RTT0 |
| Accessions | CAE91811 EAW53542 EAW53543 Q6UY14 AF217974 AAG17217 AF289612 AAL55796 AF370411 AAQ15247 AI637480 AK023606 BAB14619 AK092509 AK293037 BAF85726 AL122085 CAB59258 AL513944 AY358122 AAQ88489 BC027478 AAH27478 BC071852 AAH71852 BC094811 AAH94811 BC140800 AAI40801 BC144581 AAI44582 BC167841 AAI67841 BG005397 BM148104 BM721520 BX282114 BX370116 BX647294 CB960863 CB988088 CX164541 HY002139 XM_011509644 XP_011507946 XM_011509645 XP_011507947 XM_011509646 XP_011507948 XM_011509647 XP_011507949 XM_011509648 XP_011507950 XM_011509649 XP_011507951 XM_011509650 XP_011507952 XM_011509651 XP_011507953 XM_011509652 XP_011507954 XR_921844 NM_001288607 NP_001275536 NM_001288608 NP_001275537 NM_019032 NP_061905 NM_025008 NP_079284 |
| Function | Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. {ECO:0000269|PubMed:16364318, ECO:0000269|PubMed:21989719}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:21989719}. Note=Colocalizes with FMN1 microfibrils in the eye ECM. |
| Tissue Specificity | Expressed in colon, heart, leukocyte, liver, lung, skeletal muscle, spleen, testis and placenta. Weaker expression in bone marrow, brain tissue, kidney and pancreas. Expression studies in fetal tissues reveal strong expression in heart, kidney, liver, lung and skeletal muscle, but weaker expression in fetal brain and skin. {ECO:0000269|PubMed:19200529}. |
ADAMTS-L4 CRISPR/Cas9 KO Plasmid (h) - sc-407316 from Santa Cruz Biotechnology
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ADAMTS-L4 HDR Plasmid (h) - sc-407316-HDR from Santa Cruz Biotechnology
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ADAMTS-L4 Double Nickase Plasmid (h) - sc-407316-NIC from Santa Cruz Biotechnology
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ADAMTS-L4 Double Nickase Plasmid (h2) - sc-407316-NIC-2 from Santa Cruz Biotechnology
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ADAMTS-L4 CRISPR Activation Plasmid (h) - sc-407316-ACT from Santa Cruz Biotechnology
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ADAMTS-L4 CRISPR Activation Plasmid (h2) - sc-407316-ACT-2 from Santa Cruz Biotechnology
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ADAMTS-L4 Lentiviral Activation Particles (h) - sc-407316-LAC from Santa Cruz Biotechnology
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ADAMTS-L4 Lentiviral Activation Particles (h2) - sc-407316-LAC-2 from Santa Cruz Biotechnology
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ADAMTS-L4 siRNA (h) - sc-88067 from Santa Cruz Biotechnology
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ADAMTS-L4 shRNA Plasmid (h) - sc-88067-SH from Santa Cruz Biotechnology
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ADAMTS-L4 shRNA (h) Lentiviral Particles - sc-88067-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU118011 from Sigma-Aldrich
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MISSION® esiRNA - EHU149031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2843 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2843 from Sigma-Aldrich
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ADAMTSL4 siRNA (Human) - CRJ0102 from Cohesion Biosciences
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ADAMTSL4 - MBS8222803 from MyBioSource
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shRNA set against Human ADAMTSL4 (NM_025008.3) - SHH231982 from Creative biogene
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shRNA set against Human ADAMTSL4(NM_019032.4) - SHG040357 from Creative biogene
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shRNA set against Human ADAMTSL4(NM_025008.3) - SHG040393 from Creative biogene
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ADAMTSL4 shRNA Plasmid (Human) - CHJ0102 from Cohesion Biosciences
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ADAMTSL4 miRNA 3'UTR clone - MiUTR1H-00180 from Creative biogene
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ADAMTSL4 miRNA 3'UTR clone - MiUTR1H-00181 from Creative biogene
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