| Gene Symbol | Lgals3 |
|---|---|
| Entrez Gene | 83781 |
| Alt Symbol | AGE-R3, CBP30, L-34, gal-3 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | lectin, galactoside-binding, soluble, 3 |
| Other Description | 35 kDa lectin|CBP 35|IgE binding protein|carbohydrate-binding protein 35|epsilon BP|galactose-specific lectin 3|galectin-3|igE-binding protein|laminin-binding protein|lectin L-29|lectin galactoside-binding soluble 3 protein|lectin, galactose binding, soluble 3|mac-2 antigen |
| Swissprots | P08699 |
| Accessions | EDL88350 EDL88351 EDL88352 EDL88353 EDL88354 EDL88355 EDL88356 P08699 BC089054 AAH89054 FQ210101 FQ214799 FQ218337 FQ219929 FQ219987 FQ220157 FQ220174 FQ220215 FQ220224 FQ220313 FQ220316 FQ220348 FQ220361 FQ220369 FQ220439 FQ220450 FQ220455 FQ220487 FQ220505 FQ220541 FQ220563 FQ220590 FQ220652 FQ220701 FQ220837 FQ220917 FQ220938 FQ220946 FQ220952 FQ221377 FQ223467 FQ223525 FQ223531 FQ229211 FQ229249 FQ229259 FQ229266 FQ229277 FQ229326 FQ229348 FQ229362 FQ229490 FQ229494 FQ229511 FQ229560 FQ229562 FQ229564 FQ229577 FQ229661 FQ229821 FQ229967 FQ229990 FQ229991 FQ229995 FQ230027 FQ230050 FQ230072 FQ230121 FQ230149 J02962 AAA40828 KF639951 AHB20281 KF639952 AHB20282 KF639953 AHB20283 KF639954 AHB20284 KF639955 AHB20285 KF639956 AHB20286 KF639957 AHB20287 KF639958 AHB20288 M13697 AAA41378 NM_031832 NP_114020 |
| Function | Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells (By similarity). Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. {ECO:0000250, ECO:0000269|PubMed:11121438}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}. Note=Secreted by a non- classical secretory pathway and associates with the cell surface. {ECO:0000250}. |