| Gene Symbol |
MDFI
|
| Entrez Gene |
4188
|
| Alt Symbol |
I-MF, I-mfa
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MyoD family inhibitor
|
| Other Description |
inhibitor of MyoD family a|myoD family inhibitor|myogenic repressor I-mf
|
| Swissprots |
Q99750
|
| Accessions |
EAX04051 EAX04052 EAX04053 Q99750 AK290735 BAF83424 BC007836 AAH07836 BG818571 BI824391 BJ989485 BX397111 CA393148 CA487393 HY007825 JF432465 ADZ15682 U78313 AAB39748 XM_005249117 XP_005249174 XM_005249118 XP_005249175 XM_011514625 XP_011512927 XM_011514626 XP_011512928 NM_001300804 NP_001287733 NM_001300805 NP_001287734 NM_001300806 NP_001287735 NM_005586 NP_005577
|
| Function |
Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
|