| Gene Symbol |
Morf4l1
|
| Entrez Gene |
21761
|
| Alt Symbol |
MORFRG15, MRG15, TEG-189, Tex189, mKIAA4002
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
mortality factor 4 like 1
|
| Other Description |
MORF-related gene 15 protein|mortality factor 4-like protein 1|testis expressed gene 189|testis-expressed gene 189 protein|transcription factor-like protein MRG15
|
| Swissprots |
P60762 Q99MQ0 Q8BNY9
|
| Accessions |
AAL67900 EDL20902 EDL20904 P60762 AB042241 BAB58904 AF319620 AAK07406 AF319621 AAK07407 AK010528 AK011249 AK011441 AK016414 BAB30219 AK041833 AK079115 BAC37546 AK146210 BAE26980 AK146785 BAE27430 AK150925 BAE29963 AK152119 AK153545 BAE32082 AK164251 AK167079 BAE39239 AK168327 BAE40266 AK168585 BAE40454 AK168608 BAE40475 AK168674 BAE40524 AK169065 BAE40852 AK181499 AK182186 AK182816 AK183684 AK184930 AK185642 AK187780 AK190529 AK198286 AK201933 AK205535 AK205871 AK207086 AK207233 AK208721 AK211227 AK211776 AK212639 AK212964 AK213016 AK213758 AK214297 AK214633 AK214961 AK214973 AK215083 AK215514 AK215974 AK216220 AK216852 AK218105 AK218718 AK218976 AK220441 BAD90270 BC003894 AAH03894 BC017619 AAH17619 BC083094 BC083118 AAH83118 BC085103 AAH85103 BC092293 AAH92293 BC103783 AAI03784 X80420 XM_006511018 XP_006511081 NM_001039147 NP_001034236 NM_024431 NP_077751
|
| Function |
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR)
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00972}.
|