COL4A4

Gene Symbol	COL4A4
Entrez Gene	1286
Alt Symbol	CA44
Species	Human
Gene Type	protein-coding
Description	collagen, type IV, alpha 4
Other Description	Collagen IV, alpha-4 polypeptide|collagen alpha-4(IV) chain|collagen of basement membrane, alpha-4 chain
Swissprots	A8MTZ1 Q53WR1 Q53RW9 Q53S42 P53420
Accessions	AAY14670 AAY24061 BAA25065 CAA76763 EAW70845 EAW70846 EAW70847 P53420 AA831056 BC065843 BX094848 D17391 BAA04214 X81053 CAA56943 XM_005246281 XP_005246338 XM_005246282 XP_005246339 XM_006712246 XP_006712309 XM_006712249 XP_006712312 XM_006712251 XP_006712314 XM_006712252 XP_006712315 XM_011510557 XP_011508859 XM_011510558 XP_011508860 XM_011510559 XP_011508861 XM_011510560 XP_011508862 XM_011510561 XP_011508863 XM_011510562 XP_011508864 XM_011510563 XP_011508865 XM_011510564 XP_011508866 XM_011510565 XP_011508867 XM_011510566 XP_011508868 XM_011510567 XP_011508869 XM_011510568 XP_011508870 XM_011510569 XP_011508871 XM_011510570 XP_011508872 XM_011510571 XP_011508873 XM_011510572 XP_011508874 XR_922837 XR_922838 XR_922839 XR_922840 NM_000092 NP_000083
Function	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000255|PROSITE-ProRule:PRU00736}. Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). {ECO:0000250}.
Tissue Specificity	Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression of alpha 3 and alpha 4 type IV collagens in kidney, but PubMed:7523402 reports that in kidney levels of alpha 3 type IV collagen are significantly lower than those of alpha 4 type IV collagen. Highest levels of expression of alpha 4 type IV collagen are detected in kidney, calvaria, neuroretina and cardiac muscle. Lower levels of expression are observed in brain, lung and thymus, and no expression is detected in choroid plexus, liver, adrenal, pancreas, ileum or skin. {ECO:0000269|PubMed:7523402, ECO:0000269|PubMed:8083201}.
Top Pathways	Focal adhesion, ECM-receptor interaction, Small cell lung cancer, Amoebiasis, Protein digestion and absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

COL4A4 (E-14) - sc-167523 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

COL4A4 (G-12) - sc-167524 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Collagen alpha-4(IV) chain antibody - ab193951 from Abcam Prices $242.00 Sizes 200 µl Host Goat Clonality Polyclonal

Anti-COL4A4 / Collagen IV Antibody (aa541-590) - LS-C119457 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COL4A4 / Collagen IV Antibody (C-Terminus) - LS-C145052 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-COL4A4 / Collagen IV Antibody (C-Terminus) - LS-C153398 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COL4A4 / Collagen IV Antibody (aa1461-1690) - LS-C311517 from LifeSpan Bioscience Prices $250.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Collagen IV alpha4 Antibody - NBP1-71564 from Novus Biologicals Prices $229.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

COL4A4 Antibody (OAAF02902) - OAAF02902 from Aviva Systems Biology Prices $289.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Collagen IV alpha 4 antibody - 70R-32364 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Collagen type IV alpha 4 chain antibody - AP54854SU-N from Acris Antibodies Prices $460.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Collagen Type IV antibody - 19674-1-AP from Proteintech Group Prices $279.00 Sizes con: 65 μg/150μl Host Rabbit Clonality Polyclonal

Anti-COL4A4 antibody - STJ92392 from St John's Laboratory Ltd Host Rabbit Clonality Polyclonal

Collagen type IV Antibody - 251737 from ABBIOTEC Prices $292.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone Col-30

Collagen IV A4 Polyclonal Antibody - PA001267-C12198 from Syd Labs Prices $150.00, $250.00 Sizes 50 µg, 100 µg Host Rabbit Clonality Polyclonal

Collagen IV α4 Antibody - E11-12198C from Enogene Prices $225.00 Sizes 100 μg Host Rabbit

Collagen IV alpha4 Antibody - C12198 from Assay Biotechnology Prices $175.00, $275.00 Sizes 50 µl, 100 µl Host Rabbit Clonality Polyclonal

Human Collagen IV alpha4 Antibody - GWB-ASE082 from Genway Biotech Prices $180.00, $300.00 Sizes 50 μg, 100 μg Host Rabbit Clonality Polyclonal

COL4A4, Polyclonal Antibody - MBS423199 from MyBioSource Prices $225.00 Sizes 100 µg Host Goat Clonality Polyclonal

COL4A4-Specific, Polyclonal Antibody - MBS2529785 from MyBioSource Prices $195.00, $270.00, $435.00 Sizes 60 µl, 120 µl, 200 µl Host Rabbit Clonality Polyclonal

COL4A4-Specific Antibody - EPP11739 from Elabscience Prices $296.00, $485.00 Sizes 120 μl, 200 μl Host Rabbit Clonality Polyclonal

Anti-COL4A4 (internal region) polyclonal antibody - DPAB-DC530 from Creative Diagnostics Host Rabbit Clonality Polyclonal

Collagen Type IV Antibody Biotin Conjugated - 600-406-106 from Rockland Immunochemicals Inc Prices $319.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Collagen Type IV Antibody Fluorescein Conjugated - 600-402-106 from Rockland Immunochemicals Inc Prices $319.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Collagen Type IV Antibody Peroxidase Conjugated - 600-403-106 from Rockland Immunochemicals Inc Prices $319.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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